2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(1-methyl-1H-pyrazol-4-yl)quinazolin-4-amine

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Chemical Name:2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(1-methyl-1H-pyrazol-4-yl)quinazolin-4-amine
CAS No.:1362910-76-6
Molecular Formula:C₂₃H₁₈F₃N₇
Molecular Weight:449.438
Hs Code.:

Synonyms:2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(1-methyl-1H-pyrazol-4-yl)quinazolin-4-amine

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Chemical Property of 2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(1-methyl-1H-pyrazol-4-yl)quinazolin-4-amine

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Technology Process of 2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(1-methyl-1H-pyrazol-4-yl)quinazolin-4-amine

There total 3 articles about 2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(1-methyl-1H-pyrazol-4-yl)quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31230-17-8
3-methyl-5-aminopyrazole

: 1362910-85-7
2-(difluoro(4-fluorophenyl)methyl)-7-(1-methyl-1H-pyrazol-4-yl)quinazolin-4-ol

: 1362910-76-6
2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(1-methyl-1H-pyrazol-4-yl)quinazolin-4-amine

Guidance literature:: 2-(difluoro(4-fluorophenyl)methyl)-7-(1-methyl-1H-pyrazol-4-yl)quinazolin-4-ol; With N-ethyl-N,N-diisopropylamine; phosphorus(V) oxybromide; In toluene; at 120 ℃; for 2h;

With sodium chloride; In water; ethyl acetate;

3-methyl-5-aminopyrazole; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 112253-70-0
2-amino-4-bromobenzamide

: 1362910-76-6
2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(1-methyl-1H-pyrazol-4-yl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 0.33 h / 160 °C / Microwave irradiation; Inert atmosphere

2.1: trimethylsilyl polyphosphate / 130 °C

3.1: N-ethyl-N,N-diisopropylamine; phosphorus(V) oxybromide / toluene / 2 h / 120 °C

3.3: 0 - 20 °C

With sodium carbonate; N-ethyl-N,N-diisopropylamine; phosphorus(V) oxybromide; bis-triphenylphosphine-palladium(II) chloride; In water; toluene; acetonitrile;

Reference yield:

: 1362910-84-6
2-amino-4-(1-methyl-1H-pyrazol-4-yl)benzamide

: 1362910-76-6
2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(1-methyl-1H-pyrazol-4-yl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylsilyl polyphosphate / 130 °C

2.1: N-ethyl-N,N-diisopropylamine; phosphorus(V) oxybromide / toluene / 2 h / 120 °C

2.3: 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; phosphorus(V) oxybromide; In toluene;