S-8-oxo-8-(phenylamino)octyl ethanethioate

Base Information

• Chemical Name: S-8-oxo-8-(phenylamino)octyl ethanethioate
• CAS No.: 329966-80-5
• Molecular Formula: C₁₆H₂₃NO₂S
• Molecular Weight: 293.43
• Mol file: 329966-80-5.mol

Synonyms:S-8-oxo-8-(phenylamino)octyl ethanethioate

Chemical Property of S-8-oxo-8-(phenylamino)octyl ethanethioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-8-oxo-8-(phenylamino)octyl ethanethioate

There total 2 articles about S-8-oxo-8-(phenylamino)octyl ethanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-bromo-n-octanoyl chloride (73674-09-6) → S-8-oxo-8-(phenylamino)octyl ethanethioate (329966-80-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 20 °C

2: ethanol / 20 °C

With triethylamine; In ethanol; dichloromethane;

DOI:10.1021/jm049207j

Reference yield:

azelaic acid (123-99-9,26776-28-3) → S-8-oxo-8-(phenylamino)octyl ethanethioate (329966-80-5)

Guidance literature:

Multi-step reaction with 7 steps

1.1: toluene-4-sulfonic acid / toluene / 8 h / Reflux

2.1: sodium hydroxide / ethanol / 1 h / 20 °C

3.1: potassium hydroxide; silver nitrate / water / 0.33 h / 20 °C

3.2: 1.5 h / Cooling with ice

4.1: water; sodium hydroxide / 2 h / 45 °C

5.1: thionyl chloride / 1 h / Reflux

6.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Cooling with ice

7.1: ethanol / 20 h / 20 °C

With thionyl chloride; water; toluene-4-sulfonic acid; silver nitrate; triethylamine; potassium hydroxide; sodium hydroxide; In ethanol; dichloromethane; water; toluene;

DOI:10.1007/s00044-011-9879-7

Reference yield: 67.1%

S-8-oxo-8-(phenylamino)octyl ethanethioate (329966-80-5) → 8-mercapto-N-phenyloctanamide

Guidance literature:

With water; sodium hydroxide; In ethanol; at 20 ℃; for 48h;

DOI:10.1016/j.bmcl.2010.03.112

upstream raw materials:

8-bromo-n-octanoyl chloride

azelaic acid