6-chloro-9-(5-O-trityl-2-deoxy-β-D-threo-pentofuranosyl)-2-tritylaminopurine

Base Information

Chemical Name:6-chloro-9-(5-O-trityl-2-deoxy-β-D-threo-pentofuranosyl)-2-tritylaminopurine
CAS No.:933773-95-6
Molecular Formula:C₄₈H₄₀ClN₅O₃
Molecular Weight:770.33
Hs Code.:

Synonyms:6-chloro-9-(5-O-trityl-2-deoxy-β-D-threo-pentofuranosyl)-2-tritylaminopurine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-chloro-9-(5-O-trityl-2-deoxy-β-D-threo-pentofuranosyl)-2-tritylaminopurine

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Technology Process of 6-chloro-9-(5-O-trityl-2-deoxy-β-D-threo-pentofuranosyl)-2-tritylaminopurine

There total 3 articles about 6-chloro-9-(5-O-trityl-2-deoxy-β-D-threo-pentofuranosyl)-2-tritylaminopurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 933773-94-5,141771-78-0
2-amino-6-chloro-9-(2-deoxy-β-D-threo-pentofuranosyl)purine

: 76-83-5
trityl chloride

: 933773-95-6
6-chloro-9-(5-O-trityl-2-deoxy-β-D-threo-pentofuranosyl)-2-tritylaminopurine

Guidance literature:: With dmap; triethylamine; In N,N-dimethyl-formamide; at 45 ℃; for 24h;
DOI:10.1080/15257770600686394

Reference yield:

: 749244-34-6
2-amino-6-chloro-9-(2-O-tosyl-β-D-ribofuranosyl)purine

: 933773-95-6
6-chloro-9-(5-O-trityl-2-deoxy-β-D-threo-pentofuranosyl)-2-tritylaminopurine

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / lithium triethylborohydride / dimethylsulfoxide; tetrahydrofuran / 14 h / 35 °C

2: 96 percent / triethylamine; 4-(dimethylamino)pyridine / dimethylformamide / 24 h / 45 °C

With dmap; lithium triethylborohydride; triethylamine; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1080/15257770600686394

Reference yield:

: 2004-07-1
2-Amino-6-chloropurine riboside

: 933773-95-6
6-chloro-9-(5-O-trityl-2-deoxy-β-D-threo-pentofuranosyl)-2-tritylaminopurine

Guidance literature:: Multi-step reaction with 3 steps

1.1: dibutyltin(IV) oxide / methanol / 1 h / Heating

1.2: 85 percent / triethylamine / methanol / 12 h / 4 °C

2.1: 83 percent / lithium triethylborohydride / dimethylsulfoxide; tetrahydrofuran / 14 h / 35 °C

3.1: 96 percent / triethylamine; 4-(dimethylamino)pyridine / dimethylformamide / 24 h / 45 °C

With dmap; di(n-butyl)tin oxide; lithium triethylborohydride; triethylamine; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1080/15257770600686394