Technology Process of (S)-2-(4-methylphenyl)cyclooctanone
There total 3 articles about (S)-2-(4-methylphenyl)cyclooctanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
cycloheptanone;
With
C33H29N3O3; scandium tris(trifluoromethanesulfonate);
In
toluene;
for 0.25h;
Inert atmosphere;
p-tolyldiazomethane;
In
toluene;
at -78 ℃;
for 3h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/ol200402m
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrazine hydrate / 12 h / 90 °C / Inert atmosphere; Neat (no solvent)
2.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / diethyl ether; dichloromethane / 0.75 h / -78 °C / Inert atmosphere
3.1: C33H29N3O3; scandium tris(trifluoromethanesulfonate) / toluene / 0.25 h / Inert atmosphere
3.2: 3 h / -78 °C / Inert atmosphere
With
oxalyl dichloride; C33H29N3O3; hydrazine hydrate; dimethyl sulfoxide; triethylamine; scandium tris(trifluoromethanesulfonate);
In
diethyl ether; dichloromethane; toluene;
DOI:10.1021/ol200402m
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / diethyl ether; dichloromethane / 0.75 h / -78 °C / Inert atmosphere
2.1: C33H29N3O3; scandium tris(trifluoromethanesulfonate) / toluene / 0.25 h / Inert atmosphere
2.2: 3 h / -78 °C / Inert atmosphere
With
oxalyl dichloride; C33H29N3O3; dimethyl sulfoxide; triethylamine; scandium tris(trifluoromethanesulfonate);
In
diethyl ether; dichloromethane; toluene;
DOI:10.1021/ol200402m
