(E)-(4R,5S)-4-Benzyloxy-5-[(E)-(S)-5-((R)-3-hydroxy-butyryloxy)-hex-2-enoyloxy]-hex-2-enoic acid

Base Information

Chemical Name:(E)-(4R,5S)-4-Benzyloxy-5-[(E)-(S)-5-((R)-3-hydroxy-butyryloxy)-hex-2-enoyloxy]-hex-2-enoic acid
CAS No.:455934-74-4
Molecular Formula:C₂₃H₃₀O₈
Molecular Weight:434.486
Hs Code.:

Synonyms:(E)-(4R,5S)-4-Benzyloxy-5-[(E)-(S)-5-((R)-3-hydroxy-butyryloxy)-hex-2-enoyloxy]-hex-2-enoic acid

Suppliers and Price of (E)-(4R,5S)-4-Benzyloxy-5-[(E)-(S)-5-((R)-3-hydroxy-butyryloxy)-hex-2-enoyloxy]-hex-2-enoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-(4R,5S)-4-Benzyloxy-5-[(E)-(S)-5-((R)-3-hydroxy-butyryloxy)-hex-2-enoyloxy]-hex-2-enoic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (E)-(4R,5S)-4-Benzyloxy-5-[(E)-(S)-5-((R)-3-hydroxy-butyryloxy)-hex-2-enoyloxy]-hex-2-enoic acid

There total 9 articles about (E)-(4R,5S)-4-Benzyloxy-5-[(E)-(S)-5-((R)-3-hydroxy-butyryloxy)-hex-2-enoyloxy]-hex-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 455934-73-3
(E)-(4R,5S)-4-Benzyloxy-5-[(E)-(S)-5-((R)-3-hydroxy-butyryloxy)-hex-2-enoyloxy]-hex-2-enoic acid 2,2,2-trichloro-ethyl ester

: 455934-74-4
(E)-(4R,5S)-4-Benzyloxy-5-[(E)-(S)-5-((R)-3-hydroxy-butyryloxy)-hex-2-enoyloxy]-hex-2-enoic acid

Guidance literature:: With sodium acetate; acetic acid; zinc; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1016/S0957-4166(02)00180-5

Reference yield:

: 133522-12-0
(S,E)-5-((tert-butyldimethylsilyl)oxy)hex-2-enoic acid

: 455934-74-4
(E)-(4R,5S)-4-Benzyloxy-5-[(E)-(S)-5-((R)-3-hydroxy-butyryloxy)-hex-2-enoyloxy]-hex-2-enoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / DCC; DMAP / CH₂Cl₂ / 24 h / 20 °C

2: 93 percent / AcOH; H₂O / tetrahydrofuran / 5 h / 80 °C

3: 88 percent / DCC; DMAP; (+)-CSA / CH₂Cl₂ / 1 h / 20 °C

4: 93 percent / AcOH; H₂O / tetrahydrofuran / 3 h / 80 °C

5: 90 percent / AcOH; AcONa; Zn / tetrahydrofuran / 3 h / 20 °C

With dmap; (1S)-10-camphorsulfonic acid; water; sodium acetate; acetic acid; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0957-4166(02)00180-5

Reference yield:

: 133522-08-4
methyl (2E,5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-2-hexenoate

: 455934-74-4
(E)-(4R,5S)-4-Benzyloxy-5-[(E)-(S)-5-((R)-3-hydroxy-butyryloxy)-hex-2-enoyloxy]-hex-2-enoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / aq. NaOH / methanol / 12 h / 20 °C

2: 67 percent / DCC; DMAP / CH₂Cl₂ / 24 h / 20 °C

3: 93 percent / AcOH; H₂O / tetrahydrofuran / 5 h / 80 °C

4: 88 percent / DCC; DMAP; (+)-CSA / CH₂Cl₂ / 1 h / 20 °C

5: 93 percent / AcOH; H₂O / tetrahydrofuran / 3 h / 80 °C

6: 90 percent / AcOH; AcONa; Zn / tetrahydrofuran / 3 h / 20 °C

With dmap; sodium hydroxide; (1S)-10-camphorsulfonic acid; water; sodium acetate; acetic acid; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0957-4166(02)00180-5