2-<2-(p-nitrobenzyloxycarbonyl)-5-pyrrolidinyl>butanoic acid hydrochloride

Base Information

Chemical Name:2-<2-(p-nitrobenzyloxycarbonyl)-5-pyrrolidinyl>butanoic acid hydrochloride
CAS No.:84911-31-9
Molecular Formula:C₁₆H₂₀N₂O₆*ClH
Molecular Weight:372.806
Hs Code.:

Synonyms:2-<2-(p-nitrobenzyloxycarbonyl)-5-pyrrolidinyl>butanoic acid hydrochloride

Suppliers and Price of 2-<2-(p-nitrobenzyloxycarbonyl)-5-pyrrolidinyl>butanoic acid hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-<2-(p-nitrobenzyloxycarbonyl)-5-pyrrolidinyl>butanoic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-<2-(p-nitrobenzyloxycarbonyl)-5-pyrrolidinyl>butanoic acid hydrochloride

There total 7 articles about 2-<2-(p-nitrobenzyloxycarbonyl)-5-pyrrolidinyl>butanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 84911-29-5
2-<1-(tert-butoxycarbonyl)-2-(p-nitrobenzyloxycarbonyl)-5-pyrrolidinyl>butanoic acid

: 84911-31-9
2-<2-(p-nitrobenzyloxycarbonyl)-5-pyrrolidinyl>butanoic acid hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; for 2.5h; Ambient temperature;
DOI:10.1021/jo00157a010

Reference yield:

: 84911-17-1
Ethyl 5-Thioxopyrrolidine-2-carboxylate

: 84911-31-9
2-<2-(p-nitrobenzyloxycarbonyl)-5-pyrrolidinyl>butanoic acid hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 61 percent / NaHCO₃ / CH₂Cl₂ / 36 h / Heating

2: 39 percent / H₂ / PtO₂ / acetic acid; trifluoroacetic acid / 24 h / 3040 Torr / Ambient temperature

3: KOH / H₂O / 12 h / Ambient temperature

4: H₂O / 2-methyl-propan-2-ol / 18 h

5: 29 percent / KI, dicyclohexylamine / dimethylformamide / 19 h / 100 °C

6: 100 percent / 1N HCl / ethyl acetate / 2.5 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; water; hydrogen; sodium hydrogencarbonate; N-cyclohexyl-cyclohexanamine; potassium iodide; platinum(IV) oxide; In dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; trifluoroacetic acid; tert-butyl alcohol;
DOI:10.1021/jo00157a010

Reference yield:

: 84927-07-1
Ethyl 2-<2-(Ethoxycarbonyl)-5-pyrrolidinylidene>-3-oxobutyrate

: 84911-31-9
2-<2-(p-nitrobenzyloxycarbonyl)-5-pyrrolidinyl>butanoic acid hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 39 percent / H₂ / PtO₂ / acetic acid; trifluoroacetic acid / 24 h / 3040 Torr / Ambient temperature

2: KOH / H₂O / 12 h / Ambient temperature

3: H₂O / 2-methyl-propan-2-ol / 18 h

4: 29 percent / KI, dicyclohexylamine / dimethylformamide / 19 h / 100 °C

5: 100 percent / 1N HCl / ethyl acetate / 2.5 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; water; hydrogen; N-cyclohexyl-cyclohexanamine; potassium iodide; platinum(IV) oxide; In water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; trifluoroacetic acid; tert-butyl alcohol;
DOI:10.1021/jo00157a010