(R)-1-(1,3-dioxo-2-thiazol-5-ylmethyl-2,3-dihydro-1H-isoindol-4-yl)-piperidine-3-carboxylic acid 2-methoxy-benzylamide

Base Information

Chemical Name:(R)-1-(1,3-dioxo-2-thiazol-5-ylmethyl-2,3-dihydro-1H-isoindol-4-yl)-piperidine-3-carboxylic acid 2-methoxy-benzylamide
CAS No.:1381925-02-5
Molecular Formula:C₂₆H₂₆N₄O₄S
Molecular Weight:490.583
Hs Code.:

Synonyms:(R)-1-(1,3-dioxo-2-thiazol-5-ylmethyl-2,3-dihydro-1H-isoindol-4-yl)-piperidine-3-carboxylic acid 2-methoxy-benzylamide

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Chemical Property of (R)-1-(1,3-dioxo-2-thiazol-5-ylmethyl-2,3-dihydro-1H-isoindol-4-yl)-piperidine-3-carboxylic acid 2-methoxy-benzylamide

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Technology Process of (R)-1-(1,3-dioxo-2-thiazol-5-ylmethyl-2,3-dihydro-1H-isoindol-4-yl)-piperidine-3-carboxylic acid 2-methoxy-benzylamide

There total 2 articles about (R)-1-(1,3-dioxo-2-thiazol-5-ylmethyl-2,3-dihydro-1H-isoindol-4-yl)-piperidine-3-carboxylic acid 2-methoxy-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1381925-25-2
4-fluoro-2-thiazol-5-ylmethyl-isoindole-1,3-dione

: 1381925-22-9
(R)-piperidine-3-carboxylic acid 2-methoxy-benzylamide

: 1381925-02-5
(R)-1-(1,3-dioxo-2-thiazol-5-ylmethyl-2,3-dihydro-1H-isoindol-4-yl)-piperidine-3-carboxylic acid 2-methoxy-benzylamide

Guidance literature:: With caesium carbonate; In dimethyl sulfoxide; at 85 ℃;

Reference yield:

: 498-95-3,25137-00-2,59045-82-8,60252-41-7,262853-93-0
(R)-nipecotic acid

: 1381925-02-5
(R)-1-(1,3-dioxo-2-thiazol-5-ylmethyl-2,3-dihydro-1H-isoindol-4-yl)-piperidine-3-carboxylic acid 2-methoxy-benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; di-tert-butyl dicarbonate / chloroform / 1 h / 60 °C

1.2: 20 °C

2.1: caesium carbonate / dimethyl sulfoxide / 85 °C

With di-tert-butyl dicarbonate; caesium carbonate; triethylamine; In chloroform; dimethyl sulfoxide;