4-[(2,2-dideuterio-2-[13C]-1-methyl)ethenyl]-1-cyclohexene-1-carboxaldehyde ethylene ketal

Base Information

• Chemical Name: 4-[(2,2-dideuterio-2-[13C]-1-methyl)ethenyl]-1-cyclohexene-1-carboxaldehyde ethylene ketal
• CAS No.: 191669-64-4
• Molecular Formula: C₁₂H₁₈O₂
• Molecular Weight: 197.247
• Mol file: 191669-64-4.mol

Synonyms:4-[(2,2-dideuterio-2-[13C]-1-methyl)ethenyl]-1-cyclohexene-1-carboxaldehyde ethylene ketal

Chemical Property of 4-[(2,2-dideuterio-2-[13C]-1-methyl)ethenyl]-1-cyclohexene-1-carboxaldehyde ethylene ketal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(2,2-dideuterio-2-[13C]-1-methyl)ethenyl]-1-cyclohexene-1-carboxaldehyde ethylene ketal

There total 1 articles about 4-[(2,2-dideuterio-2-[13C]-1-methyl)ethenyl]-1-cyclohexene-1-carboxaldehyde ethylene ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[13C2H3] methyl iodide (20710-47-8,207507-22-0) + 1-((S)-4-[1,3]Dioxolan-2-yl-cyclohex-3-enyl)-ethanone (191669-63-3) → 4-[(2,2-dideuterio-2-[13C]-1-methyl)ethenyl]-1-cyclohexene-1-carboxaldehyde ethylene ketal (191669-64-4)

Guidance literature:

With n-butyllithium; triphenylphosphine; Yield given. Multistep reaction;

DOI:10.1002/(SICI)1099-1344(199705)39:5<369::AID-JLCR983>3.0.CO;2-F

Reference yield: 92.0%

4-[(2,2-dideuterio-2-[13C]-1-methyl)ethenyl]-1-cyclohexene-1-carboxaldehyde ethylene ketal (191669-64-4) → [(2,2-dideuterio-2-[13C]-1-methyl)ethenyl]-1-cyclohexene-1-carboxaldehyde

Guidance literature:

With sulfuric acid; In methanol; for 4h; Ambient temperature;

DOI:10.1002/(SICI)1099-1344(199705)39:5<369::AID-JLCR983>3.0.CO;2-F

Reference yield:

4-[(2,2-dideuterio-2-[13C]-1-methyl)ethenyl]-1-cyclohexene-1-carboxaldehyde ethylene ketal (191669-64-4) → [(1,1-dideuterio-1-[13C]-2-methyl)ethenyl]-1-cyclohexene-1-carboxylic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / 1N aq. H₂SO₄ / methanol / 4 h / Ambient temperature

2: 60 percent / AgNO₃, aq. NaOH / ethanol / Ambient temperature

With sodium hydroxide; sulfuric acid; silver nitrate; In methanol; ethanol;

DOI:10.1002/(SICI)1099-1344(199705)39:5<369::AID-JLCR983>3.0.CO;2-F

upstream raw materials:

[13C₂H₃] methyl iodide

1-((S)-4-[1,3]Dioxolan-2-yl-cyclohex-3-enyl)-ethanone