(2S,3S,4S)-(+)-1-<(tert-butyldiphenylsilyl)oxy>-2,4-dimethyl-5-hexyn-3-ol

Base Information

Chemical Name:(2S,3S,4S)-(+)-1-<(tert-butyldiphenylsilyl)oxy>-2,4-dimethyl-5-hexyn-3-ol
CAS No.:227792-06-5
Molecular Formula:C₂₄H₃₂O₂Si
Molecular Weight:380.602
Hs Code.:

Synonyms:(2S,3S,4S)-(+)-1-<(tert-butyldiphenylsilyl)oxy>-2,4-dimethyl-5-hexyn-3-ol

Suppliers and Price of (2S,3S,4S)-(+)-1-<(tert-butyldiphenylsilyl)oxy>-2,4-dimethyl-5-hexyn-3-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S,4S)-(+)-1-<(tert-butyldiphenylsilyl)oxy>-2,4-dimethyl-5-hexyn-3-ol

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Technology Process of (2S,3S,4S)-(+)-1-<(tert-butyldiphenylsilyl)oxy>-2,4-dimethyl-5-hexyn-3-ol

There total 1 articles about (2S,3S,4S)-(+)-1-<(tert-butyldiphenylsilyl)oxy>-2,4-dimethyl-5-hexyn-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 92817-88-4
(2S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-methylpropanal

: 121887-95-4
(R)-(+)-3-butyn-2-ol methanesulfonate

: (2S,3R,4S)-1-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-hex-5-yn-3-ol

: 227792-06-5
(2S,3S,4S)-(+)-1-<(tert-butyldiphenylsilyl)oxy>-2,4-dimethyl-5-hexyn-3-ol

Guidance literature:: With palladium diacetate; diethylzinc; triphenylphosphine; In tetrahydrofuran; hexane; at -20 ℃; for 24h; Yields of byproduct given;
DOI:10.1021/jo9823083

Reference yield:

: 227792-06-5
(2S,3S,4S)-(+)-1-<(tert-butyldiphenylsilyl)oxy>-2,4-dimethyl-5-hexyn-3-ol

: 142592-68-5
(5S,6S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5-methyl-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 400 mg / n-BuLi / tetrahydrofuran; hexane / 0.25 h / -40 °C

2: quinoline, H₂ / 5 percent Pd/BaSO₄ / ethanol / 1 h

3: benzene / 4 h / Heating

With quinoline; n-butyllithium; hydrogen; Pd-BaSO₄; In tetrahydrofuran; ethanol; hexane; benzene;
DOI:10.1021/jo9823083

Reference yield:

: 227792-06-5
(2S,3S,4S)-(+)-1-<(tert-butyldiphenylsilyl)oxy>-2,4-dimethyl-5-hexyn-3-ol

: 235099-38-4
(5S,6S)-6-{(1S)-2-[(tert-butyldiphenylsilyl)oxy]-1-methylethyl}-5-methyl-5,6-dihydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 400 mg / n-BuLi / tetrahydrofuran; hexane / 0.25 h / -40 °C

2: quinoline, H₂ / 5 percent Pd/BaSO₄ / ethanol / 1 h

3: 65 percent / benzene / 4 h / Heating

With quinoline; n-butyllithium; hydrogen; Pd-BaSO₄; In tetrahydrofuran; ethanol; hexane; benzene;
DOI:10.1021/jo9823083