Pradimicinone

Base Information

Chemical Name:Pradimicinone
CAS No.:116276-03-0
Molecular Formula:C28H23 N O11
Molecular Weight:549.491
Hs Code.:
Mol file:116276-03-0.mol

Synonyms:D-Alanine,N-[(5,6,8,13-tetrahydro-1,5,6,9,14-pentahydroxy-11-methoxy-3-methyl-8,13-dioxobenzo[a]naphthacen-2-yl)carbonyl]-,(5S-trans)-; Benzo[a]naphthacene, D-alanine deriv.; AG 2; BMY 28750;Benanomicinone; Pradimicinone I

Suppliers and Price of Pradimicinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Pradimicinone

Chemical Property:

Vapor Pressure:3.86E-35mmHg at 25°C
Boiling Point:903.2°C at 760 mmHg
Flash Point:500.1°C
PSA：214.41000
Density:1.647g/cm³
LogP:2.42090

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Pradimicinone

There total 12 articles about Pradimicinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 116249-67-3
benanomicinone methyl ester

: 116276-03-0
pradimicinone I

Guidance literature:: With sodium hydroxide; water; for 0.25h;
DOI:10.1002/(SICI)1521-3773(19990503)38:9<1229::AID-ANIE1229>3.0.CO;2-B

Reference yield:

: 117704-65-1
pradimicin A -5,6,8,13-tetrahydro-1,6,9,14-tetrahydroxy-11-methoxy-3-methyl-8,13-dioxobenzo<α>naphthacen-2-yl>carbonyl>-D-alanine>

: 338-69-2,25191-17-7,18875-37-1
D-Alanine

: 116249-69-5
(5S,6S)-1,5,6,9,14-Pentahydroxy-11-methoxy-3-methyl-8,13-dioxo-5,6,8,13-tetrahydro-benzo[a]naphthacene-2-carboxylic acid

: (R)-2-[(1,6,9,14-Tetrahydroxy-11-methoxy-3-methyl-8,13-dioxo-8,13-dihydro-benzo[a]naphthacene-2-carbonyl)-amino]-propionic acid

: 116276-03-0
pradimicinone I

Guidance literature:: With hydrogenchloride; at 115 ℃; for 14h;
DOI:10.1021/jo00272a013

Reference yield:

: 116249-69-5
(5S,6S)-1,5,6,9,14-Pentahydroxy-11-methoxy-3-methyl-8,13-dioxo-5,6,8,13-tetrahydro-benzo[a]naphthacene-2-carboxylic acid

: 116276-03-0
pradimicinone I

Guidance literature:: Multi-step reaction with 2 steps

1: BOP; Et₃N / dimethylformamide / 1.5 h

2: 100 percent / H₂O; NaOH / 0.25 h

With sodium hydroxide; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; 1: Condensation / 2: Hydrolysis;
DOI:10.1002/(SICI)1521-3773(19990503)38:9<1229::AID-ANIE1229>3.0.CO;2-B