methyl (E)-3-[(2R,5S)-1-(3-butenoyl)-5-(3,4-difluorophenyl)pyrrolidin-2-yl]acrylate

Base Information

Chemical Name:methyl (E)-3-[(2R,5S)-1-(3-butenoyl)-5-(3,4-difluorophenyl)pyrrolidin-2-yl]acrylate
CAS No.:958228-20-1
Molecular Formula:C₁₈H₁₉F₂NO₃
Molecular Weight:335.351
Hs Code.:

Synonyms:methyl (E)-3-[(2R,5S)-1-(3-butenoyl)-5-(3,4-difluorophenyl)pyrrolidin-2-yl]acrylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (E)-3-[(2R,5S)-1-(3-butenoyl)-5-(3,4-difluorophenyl)pyrrolidin-2-yl]acrylate

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Technology Process of methyl (E)-3-[(2R,5S)-1-(3-butenoyl)-5-(3,4-difluorophenyl)pyrrolidin-2-yl]acrylate

There total 1 articles about methyl (E)-3-[(2R,5S)-1-(3-butenoyl)-5-(3,4-difluorophenyl)pyrrolidin-2-yl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 625-38-7
but-3-enoic acid

: 958228-19-8
methyl (E)-3-[(2R,5S)-5-(3,4-difluorophenyl)pyrrolidin-2-yl]acrylate

: 958228-20-1
methyl (E)-3-[(2R,5S)-1-(3-butenoyl)-5-(3,4-difluorophenyl)pyrrolidin-2-yl]acrylate

Guidance literature:: With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;

Reference yield:

: 958228-20-1
methyl (E)-3-[(2R,5S)-1-(3-butenoyl)-5-(3,4-difluorophenyl)pyrrolidin-2-yl]acrylate

: 958228-22-3
(3S,8aR)-3-(3,4-difluorophenyl)-[2,3,6,8a]-tetrahydro-1H-indolizin-5-one

Guidance literature:: methyl (E)-3-[(2R,5S)-1-(3-butenoyl)-5-(3,4-difluorophenyl)pyrrolidin-2-yl]acrylate; dichloro(tricyclohexylphosphino)(benzylidene)(1,3-dimesityl-4,5-dihydroimidazol-2-ylidene)ruthenium(III); In dichloromethane; for 4h; Heating / reflux;

With triethylamine; In dichloromethane; at 20 ℃; for 1h;