Technology Process of 6-(2-(6-phenyl-1,2,3,4-tetrahydronaphthalene-2-carbonyl)oxazol-5-yl)picolinic acid
There total 16 articles about 6-(2-(6-phenyl-1,2,3,4-tetrahydronaphthalene-2-carbonyl)oxazol-5-yl)picolinic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 6-(2-(6-phenyl-1,2,3,4-tetrahydronaphthalene-2-carbonyl)oxazol-5-yl)picolinate;
With
water; lithium hydroxide;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
With
hydrogenchloride;
In
tetrahydrofuran; water;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: pyridine / 0 - 20 °C / Inert atmosphere
2.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / tetrahydrofuran; water / 16 h / Reflux; Inert atmosphere
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
4.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
5.1: borane-THF / tetrahydrofuran / 1 h / 20 °C
5.2: 0.67 h / -78 °C
5.3: 2 h / -78 °C
6.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C
7.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C
7.2: 0.08 h
8.1: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 16 h / Reflux; Inert atmosphere
9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
10.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
11.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C
With
pyridine; 1H-imidazole; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; borane-THF; tetrabutyl ammonium fluoride; water; sodium carbonate; Dess-Martin periodane; lithium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
2.1: Suzuki coupling / 8.1: Stille coupling;
DOI:10.1021/jm101597x
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / tetrahydrofuran; water / 16 h / Reflux; Inert atmosphere
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
3.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
4.1: borane-THF / tetrahydrofuran / 1 h / 20 °C
4.2: 0.67 h / -78 °C
4.3: 2 h / -78 °C
5.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C
6.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C
6.2: 0.08 h
7.1: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 16 h / Reflux; Inert atmosphere
8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
9.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
10.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C
With
1H-imidazole; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; borane-THF; tetrabutyl ammonium fluoride; water; sodium carbonate; Dess-Martin periodane; lithium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
1.1: Suzuki coupling / 7.1: Stille coupling;
DOI:10.1021/jm101597x
