(Z)-3-(3-hydroxy-3-(4-methoxyphenyl)acryloyl)-6,9a-dimethyl-5,6-dihydro-9aH-furo[3,2-g]isochromene-2,9-dione

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Chemical Name:(Z)-3-(3-hydroxy-3-(4-methoxyphenyl)acryloyl)-6,9a-dimethyl-5,6-dihydro-9aH-furo[3,2-g]isochromene-2,9-dione
CAS No.:1293991-72-6
Molecular Formula:C₂₃H₂₀O₇
Molecular Weight:408.408
Hs Code.:

Synonyms:(Z)-3-(3-hydroxy-3-(4-methoxyphenyl)acryloyl)-6,9a-dimethyl-5,6-dihydro-9aH-furo[3,2-g]isochromene-2,9-dione

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Chemical Property of (Z)-3-(3-hydroxy-3-(4-methoxyphenyl)acryloyl)-6,9a-dimethyl-5,6-dihydro-9aH-furo[3,2-g]isochromene-2,9-dione

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Technology Process of (Z)-3-(3-hydroxy-3-(4-methoxyphenyl)acryloyl)-6,9a-dimethyl-5,6-dihydro-9aH-furo[3,2-g]isochromene-2,9-dione

There total 9 articles about (Z)-3-(3-hydroxy-3-(4-methoxyphenyl)acryloyl)-6,9a-dimethyl-5,6-dihydro-9aH-furo[3,2-g]isochromene-2,9-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₄O₇Si

: 1293991-72-6
(Z)-3-(3-hydroxy-3-(4-methoxyphenyl)acryloyl)-6,9a-dimethyl-5,6-dihydro-9aH-furo[3,2-g]isochromene-2,9-dione

Guidance literature:: With hydrogenchloride; In water; toluene; at 20 ℃;

Reference yield:

: 5673-07-4
2,6-dimethoxytoluene

: 1293991-72-6
(Z)-3-(3-hydroxy-3-(4-methoxyphenyl)acryloyl)-6,9a-dimethyl-5,6-dihydro-9aH-furo[3,2-g]isochromene-2,9-dione

Guidance literature:: Multi-step reaction with 9 steps

1.1: aluminum (III) chloride / dichloromethane / 10 h / 20 °C / Inert atmosphere

1.2: 0 °C

2.1: N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium / hexane; tetrahydrofuran / -78 - -15 °C

2.2: 1.5 h / -78 - 20 °C

3.1: 10-camphorsulfonic acid / toluene / Reflux; Inert atmosphere

4.1: aluminum (III) chloride / dichloromethane / 16 h / Reflux

4.2: 0 °C

5.1: sodium hydride / toluene; tetrahydrofuran / 0.5 h / 20 °C

6.1: diisobutylaluminium hydride / toluene / 1 h / -78 °C

7.1: trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane / 20 °C / Inert atmosphere

8.1: triethylamine / toluene / 2 h / 100 °C / Inert atmosphere

9.1: hydrogenchloride / toluene; water / 20 °C

With hydrogenchloride; aluminum (III) chloride; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; sodium hydride; diisobutylaluminium hydride; triethylamine; 10-camphorsulfonic acid; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; hexane; dichloromethane; water; toluene;

Reference yield:

: 1293991-85-1
6,8-dihydroxy-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-one

: 1293991-72-6
(Z)-3-(3-hydroxy-3-(4-methoxyphenyl)acryloyl)-6,9a-dimethyl-5,6-dihydro-9aH-furo[3,2-g]isochromene-2,9-dione

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / toluene; tetrahydrofuran / 0.5 h / 20 °C

2: diisobutylaluminium hydride / toluene / 1 h / -78 °C

3: trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane / 20 °C / Inert atmosphere

4: triethylamine / toluene / 2 h / 100 °C / Inert atmosphere

5: hydrogenchloride / toluene; water / 20 °C

With hydrogenchloride; sodium hydride; diisobutylaluminium hydride; triethylamine; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; water; toluene;