propane-1-sulfonic acid {2-chloro-4-fluoro-3-[3-(3-methoxy-1H-pyrazolo[3,4-d]pyrimidin-4-yl)ureido]phenyl}amide

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Chemical Name:propane-1-sulfonic acid {2-chloro-4-fluoro-3-[3-(3-methoxy-1H-pyrazolo[3,4-d]pyrimidin-4-yl)ureido]phenyl}amide
CAS No.:1268831-13-5
Molecular Formula:C₁₆H₁₇ClFN₇O₄S
Molecular Weight:457.873
Hs Code.:

Synonyms:propane-1-sulfonic acid {2-chloro-4-fluoro-3-[3-(3-methoxy-1H-pyrazolo[3,4-d]pyrimidin-4-yl)ureido]phenyl}amide

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Chemical Property of propane-1-sulfonic acid {2-chloro-4-fluoro-3-[3-(3-methoxy-1H-pyrazolo[3,4-d]pyrimidin-4-yl)ureido]phenyl}amide

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Technology Process of propane-1-sulfonic acid {2-chloro-4-fluoro-3-[3-(3-methoxy-1H-pyrazolo[3,4-d]pyrimidin-4-yl)ureido]phenyl}amide

There total 6 articles about propane-1-sulfonic acid {2-chloro-4-fluoro-3-[3-(3-methoxy-1H-pyrazolo[3,4-d]pyrimidin-4-yl)ureido]phenyl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1186194-00-2
2-chloro-6-fluoro-3-(propylsulfonamido)benzoic acid

: 111375-22-5
4-amino-3-methoxy-1H-pyrazolo<3,4-d>pyrimidine

: 1268831-13-5
propane-1-sulfonic acid {2-chloro-4-fluoro-3-[3-(3-methoxy-1H-pyrazolo[3,4-d]pyrimidin-4-yl)ureido]phenyl}amide

Guidance literature:: 2-chloro-6-fluoro-3-(propylsulfonamido)benzoic acid; With diphenyl phosphoryl azide; triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

4-amino-3-methoxy-1H-pyrazolo<3,4-d>pyrimidine; In tetrahydrofuran; at 100 ℃; for 3h;

Reference yield:

: 2106-02-7
2-chloro-4-fluoroaniline

: 1268831-13-5
propane-1-sulfonic acid {2-chloro-4-fluoro-3-[3-(3-methoxy-1H-pyrazolo[3,4-d]pyrimidin-4-yl)ureido]phenyl}amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / toluene / 1 h / Reflux

2.1: n-butyllithium / tetrahydrofuran / 1.33 h / -78 °C / Inert atmosphere

2.2: 2.5 h / -78 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; triethylamine / ethanol; water / 18 h / Reflux

4.1: triethylamine / dichloromethane / 1.33 h / 0 °C

4.2: 2 h / 20 °C

5.1: potassium hydroxide; water / tetrahydrofuran / 2 h / Reflux

5.2: pH 2

6.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 3 h / 20 °C

6.2: 3 h / 100 °C

With n-butyllithium; diphenyl phosphoryl azide; hydroxylamine hydrochloride; water; toluene-4-sulfonic acid; triethylamine; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;

Reference yield:

: 1153146-10-1
1-(2-chloro-4-fluorophenyl)-2,5-dimethyl-1H-pyrrole

: 1268831-13-5
propane-1-sulfonic acid {2-chloro-4-fluoro-3-[3-(3-methoxy-1H-pyrazolo[3,4-d]pyrimidin-4-yl)ureido]phenyl}amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / 1.33 h / -78 °C / Inert atmosphere

1.2: 2.5 h / -78 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; triethylamine / ethanol; water / 18 h / Reflux

3.1: triethylamine / dichloromethane / 1.33 h / 0 °C

3.2: 2 h / 20 °C

4.1: potassium hydroxide; water / tetrahydrofuran / 2 h / Reflux

4.2: pH 2

5.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 3 h / 20 °C

5.2: 3 h / 100 °C

With n-butyllithium; diphenyl phosphoryl azide; hydroxylamine hydrochloride; water; triethylamine; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water;