2-chloro-4-(2-(1-(4-fluoro-3-methoxyphenyl)-2-mercapto-1H-imidazol-5-yl)propan-2-yl)benzenesulfonamide

Base Information

Chemical Name:2-chloro-4-(2-(1-(4-fluoro-3-methoxyphenyl)-2-mercapto-1H-imidazol-5-yl)propan-2-yl)benzenesulfonamide
CAS No.:1239963-98-4
Molecular Formula:C₁₉H₁₉ClFN₃O₃S₂
Molecular Weight:455.962
Hs Code.:

Synonyms:2-chloro-4-(2-(1-(4-fluoro-3-methoxyphenyl)-2-mercapto-1H-imidazol-5-yl)propan-2-yl)benzenesulfonamide

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Chemical Property of 2-chloro-4-(2-(1-(4-fluoro-3-methoxyphenyl)-2-mercapto-1H-imidazol-5-yl)propan-2-yl)benzenesulfonamide

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Technology Process of 2-chloro-4-(2-(1-(4-fluoro-3-methoxyphenyl)-2-mercapto-1H-imidazol-5-yl)propan-2-yl)benzenesulfonamide

There total 10 articles about 2-chloro-4-(2-(1-(4-fluoro-3-methoxyphenyl)-2-mercapto-1H-imidazol-5-yl)propan-2-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1239964-05-6
2-chloro-4-(4-(3-(4-fluoro-3-methoxyphenyl)thioureido)-2-methyl-3-oxobutan-2-yl)benzenesulfonamide

: 1239963-98-4
2-chloro-4-(2-(1-(4-fluoro-3-methoxyphenyl)-2-mercapto-1H-imidazol-5-yl)propan-2-yl)benzenesulfonamide

Guidance literature:: With acetic acid; for 3h; Reflux;

Reference yield:

: 64798-33-0
2-(3-chloro-phenyl)-2-methyl-propionitrile

: 1239963-98-4
2-chloro-4-(2-(1-(4-fluoro-3-methoxyphenyl)-2-mercapto-1H-imidazol-5-yl)propan-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 2.5 h / -78 °C

1.2: -78 - 20 °C

2.1: diethyl ether; tetrahydrofuran / 3 h / 0 - 20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C

3.2: -78 - 20 °C

4.1: sulfuryl dichloride / chloroform / 2 h / 0 °C

4.2: 0 - 20 °C / Inert atmosphere

5.1: ammonium hydroxide / tetrahydrofuran / 2 h / 0 °C

6.1: tetra-n-butylammonium tribromide / dichloromethane; methanol / 20 h

7.1: sodium azide / N,N-dimethyl-formamide / 2 h / 0 °C

8.1: hydrogenchloride; hydrogen / platinum(IV) oxide / ethanol / 2 h / 2327.23 Torr

9.1: triethylamine / dichloromethane / 1 h

10.1: acetic acid / 3 h / Reflux

With hydrogenchloride; ammonium hydroxide; sodium azide; sulfuryl dichloride; tetra-n-butylammonium tribromide; oxalyl dichloride; hydrogen; diisobutylaluminium hydride; acetic acid; dimethyl sulfoxide; triethylamine; platinum(IV) oxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1239964-00-1
2-chloro-4-(2-methyl-3-oxobutan-2-yl)benzene-1-sulfonyl chloride

: 1239963-98-4
2-chloro-4-(2-(1-(4-fluoro-3-methoxyphenyl)-2-mercapto-1H-imidazol-5-yl)propan-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: ammonium hydroxide / tetrahydrofuran / 2 h / 0 °C

2: tetra-n-butylammonium tribromide / dichloromethane; methanol / 20 h

3: sodium azide / N,N-dimethyl-formamide / 2 h / 0 °C

4: hydrogenchloride; hydrogen / platinum(IV) oxide / ethanol / 2 h / 2327.23 Torr

5: triethylamine / dichloromethane / 1 h

6: acetic acid / 3 h / Reflux

With hydrogenchloride; ammonium hydroxide; sodium azide; tetra-n-butylammonium tribromide; hydrogen; acetic acid; triethylamine; platinum(IV) oxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;