3-[(2R,3S,4aR,6S,8S,8aS)-3-Acetoxy-6-(tert-butyl-dicyclohexyl-silanyloxymethyl)-8-hydroxy-2-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-propionic acid methyl ester

Base Information

Chemical Name:3-[(2R,3S,4aR,6S,8S,8aS)-3-Acetoxy-6-(tert-butyl-dicyclohexyl-silanyloxymethyl)-8-hydroxy-2-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-propionic acid methyl ester
CAS No.:155434-23-4
Molecular Formula:C₃₂H₅₆O₈Si
Molecular Weight:596.877
Hs Code.:

3-[(2R,3S,4aR,6S,8S,8aS)-3-Acetoxy-6-(tert-butyl-dicyclohexyl-silanyloxymethyl)-8-hydroxy-2-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-propionic acid methyl ester

Synonyms:3-[(2R,3S,4aR,6S,8S,8aS)-3-Acetoxy-6-(tert-butyl-dicyclohexyl-silanyloxymethyl)-8-hydroxy-2-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-propionic acid methyl ester

Suppliers and Price of 3-[(2R,3S,4aR,6S,8S,8aS)-3-Acetoxy-6-(tert-butyl-dicyclohexyl-silanyloxymethyl)-8-hydroxy-2-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-propionic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[(2R,3S,4aR,6S,8S,8aS)-3-Acetoxy-6-(tert-butyl-dicyclohexyl-silanyloxymethyl)-8-hydroxy-2-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[(2R,3S,4aR,6S,8S,8aS)-3-Acetoxy-6-(tert-butyl-dicyclohexyl-silanyloxymethyl)-8-hydroxy-2-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-propionic acid methyl ester

There total 15 articles about 3-[(2R,3S,4aR,6S,8S,8aS)-3-Acetoxy-6-(tert-butyl-dicyclohexyl-silanyloxymethyl)-8-hydroxy-2-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 155434-12-1
(E)-3-[(2R,3S,4aR,6S,8S,8aS)-3-Acetoxy-8-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-acrylic acid methyl ester

: 155434-23-4
3-[(2R,3S,4aR,6S,8S,8aS)-3-Acetoxy-6-(tert-butyl-dicyclohexyl-silanyloxymethyl)-8-hydroxy-2-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-propionic acid methyl ester

: 155434-22-3
3-[(2R,3S,4aR,6S,8S,8aS)-3-Acetoxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-8-hydroxy-2-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-propionic acid methyl ester

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; at 25 ℃;
DOI:10.1039/c39930001638

Reference yield:

: 122821-83-4
2,6-Anhydro-4-O-benzyl-1-O-(tert-butyldiphenylsilyl)-3,7,8,9-tetradeoxy-D-altro-non-8-enitol

: 155434-23-4
3-[(2R,3S,4aR,6S,8S,8aS)-3-Acetoxy-6-(tert-butyl-dicyclohexyl-silanyloxymethyl)-8-hydroxy-2-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: 100 percent / imidazole / dimethylformamide / 3.5 h / Ambient temperature

2: 1.) O₃; 2.) Ph₃P / 1.) CH₂Cl₂, -78 deg C; 2.) CH₂Cl₂, -78 deg C to RT

3: benzene / 12 h / 80 °C

4: 95 percent / 1.0 M di-isobutylaluminum hydride / CH₂Cl₂; hexane / 1 h / -78 °C

5: 93 percent / (+)-DET, Ti(O-iPr)2, 3.0 M t-BuOOH, 4 Angstroem molecular sieves / CH₂Cl₂; 2,2,4-trimethyl-pentane / 70 h / -20 °C

6: 100 percent / SO₃*py complex, Et₃N / dimethylsulfoxide; CH₂Cl₂ / 3 h / Ambient temperature

7: 94 percent / 1.0 M NaHMDS / tetrahydrofuran / 1 h / 0 °C

8: 97 percent / 1.0 M TBAF / tetrahydrofuran / 0.25 h / 0 °C

9: 53 percent / camphorsulfonic acid / CH₂Cl₂ / 1 h / 0 °C

10: 97 percent / pyridine, 4-dimethylaminopyridine / CH₂Cl₂ / 13 h / Ambient temperature

11: 1.) O₃; 2.) PPh₃ / 1.) CH₂Cl₂, -78 deg C; 2.) CH₂Cl₂, -78 deg C to RT

12: benzene / 6.5 h / 80 °C

13: 10 percent / H₂ / Pd(OH)2-C / methanol / 20 h / Ambient temperature

With pyridine; 1H-imidazole; tert.-butylhydroperoxide; dmap; diisobutylaluminum hydride; pyridine-SO₃ complex; diethyl (2R,3R)-tartrate; titanium(II) diisopropoxide; 4 A molecular sieve; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; sodium hexamethyldisilazane; ozone; triethylamine; triphenylphosphine; palladium hydroxide - carbon; In tetrahydrofuran; methanol; 2,2,4-trimethylpentane; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene;

Reference yield:

: 155434-18-7
(2R,3S,4S,6S)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-2-((2S,3S)-3-methyl-3-vinyl-oxiranylmethyl)-tetrahydro-pyran-3-ol

: 155434-23-4
3-[(2R,3S,4aR,6S,8S,8aS)-3-Acetoxy-6-(tert-butyl-dicyclohexyl-silanyloxymethyl)-8-hydroxy-2-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 53 percent / camphorsulfonic acid / CH₂Cl₂ / 1 h / 0 °C

2: 97 percent / pyridine, 4-dimethylaminopyridine / CH₂Cl₂ / 13 h / Ambient temperature

3: 1.) O₃; 2.) PPh₃ / 1.) CH₂Cl₂, -78 deg C; 2.) CH₂Cl₂, -78 deg C to RT

4: benzene / 6.5 h / 80 °C

5: 10 percent / H₂ / Pd(OH)2-C / methanol / 20 h / Ambient temperature

With pyridine; dmap; camphor-10-sulfonic acid; hydrogen; ozone; triphenylphosphine; palladium hydroxide - carbon; In methanol; dichloromethane; benzene;