[bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 7-{3-[6-(2-hydroxy-ethyl)-3,6-dihydro-2H-pyran-2-yl]-2-methyl-propyl}-1-[1-(4-methoxy-benzyloxy)-3-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyl]-5-methoxymethoxy-octa-3,7-dienyl ester

Base Information

Chemical Name:[bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 7-{3-[6-(2-hydroxy-ethyl)-3,6-dihydro-2H-pyran-2-yl]-2-methyl-propyl}-1-[1-(4-methoxy-benzyloxy)-3-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyl]-5-methoxymethoxy-octa-3,7-dienyl ester
CAS No.:312695-84-4
Molecular Formula:C₄₄H₆₁F₆O₁₂P
Molecular Weight:926.925
Hs Code.:

[bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 7-{3-[6-(2-hydroxy-ethyl)-3,6-dihydro-2<i>H</i>-pyran-2-yl]-2-methyl-propyl}-1-[1-(4-methoxy-benzyloxy)-3-(4-methyl-3,6-dihydro-2<i>H</i>-pyran-2-yl)-allyl]-5-methoxymethoxy-octa-3,7-dienyl ester

Synonyms:[bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 7-{3-[6-(2-hydroxy-ethyl)-3,6-dihydro-2H-pyran-2-yl]-2-methyl-propyl}-1-[1-(4-methoxy-benzyloxy)-3-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyl]-5-methoxymethoxy-octa-3,7-dienyl ester

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Chemical Property of [bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 7-{3-[6-(2-hydroxy-ethyl)-3,6-dihydro-2H-pyran-2-yl]-2-methyl-propyl}-1-[1-(4-methoxy-benzyloxy)-3-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyl]-5-methoxymethoxy-octa-3,7-dienyl ester

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Technology Process of [bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 7-{3-[6-(2-hydroxy-ethyl)-3,6-dihydro-2H-pyran-2-yl]-2-methyl-propyl}-1-[1-(4-methoxy-benzyloxy)-3-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyl]-5-methoxymethoxy-octa-3,7-dienyl ester

There total 38 articles about [bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 7-{3-[6-(2-hydroxy-ethyl)-3,6-dihydro-2H-pyran-2-yl]-2-methyl-propyl}-1-[1-(4-methoxy-benzyloxy)-3-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyl]-5-methoxymethoxy-octa-3,7-dienyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: C₅₀H₇₅F₆O₁₂PSi

: 312695-84-4
[bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 7-{3-[6-(2-hydroxy-ethyl)-3,6-dihydro-2H-pyran-2-yl]-2-methyl-propyl}-1-[1-(4-methoxy-benzyloxy)-3-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyl]-5-methoxymethoxy-octa-3,7-dienyl ester

Guidance literature:: With acetic acid; In tetrahydrofuran; at 23 ℃;
DOI:10.1021/ja0027416

Reference yield:

: 289472-92-0
(2S)-2-(2,2-dibromo-vinyl)-4-methyl-3,6-dihydro-2H-pyran

: 312695-84-4
[bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 7-{3-[6-(2-hydroxy-ethyl)-3,6-dihydro-2H-pyran-2-yl]-2-methyl-propyl}-1-[1-(4-methoxy-benzyloxy)-3-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyl]-5-methoxymethoxy-octa-3,7-dienyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -78 - 23 °C

1.2: 64 percent / tetrahydrofuran / 1 h / -78 °C

2.1: 81 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.17 h / 23 °C

3.1: 87 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C

4.1: 81 percent / Red-Al / tetrahydrofuran / -40 - -20 °C

5.1: TFA / CH₂Cl₂ / 1 h / 23 °C

6.1: 71 percent / CSA / CH₂Cl₂ / 0.5 h / 23 °C

7.1: 74 percent / DIBAL / CH₂Cl₂ / 0.5 h / -78 °C

8.1: 2,4,6-trichlorobenzoyl chloride; i-Pr₂NEt; DMAP / tetrahydrofuran; benzene / 23 °C

9.1: 32 mg / AcOH / tetrahydrofuran; H₂O / 3 h / 23 °C

With dmap; n-butyllithium; 2,4,6-trichlorobenzoyl chloride; camphor-10-sulfonic acid; L-Selectride; diisobutylaluminium hydride; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; water; benzene;
DOI:10.1021/jo010854h

Reference yield:

: (E)-(3S,4S)-6-Benzenesulfonyl-1-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-hex-1-ene-3,4-diol

: 312695-84-4
[bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 7-{3-[6-(2-hydroxy-ethyl)-3,6-dihydro-2H-pyran-2-yl]-2-methyl-propyl}-1-[1-(4-methoxy-benzyloxy)-3-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyl]-5-methoxymethoxy-octa-3,7-dienyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 71 percent / CSA / CH₂Cl₂ / 0.5 h / 23 °C

2: 74 percent / DIBAL / CH₂Cl₂ / 0.5 h / -78 °C

3: 2,4,6-trichlorobenzoyl chloride; i-Pr₂NEt; DMAP / tetrahydrofuran; benzene / 23 °C

4: 32 mg / AcOH / tetrahydrofuran; H₂O / 3 h / 23 °C

With dmap; 2,4,6-trichlorobenzoyl chloride; camphor-10-sulfonic acid; diisobutylaluminium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; benzene;
DOI:10.1021/jo010854h