(1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexylmethyl 4-methylbenzenesulfonate

Base Information

Chemical Name:(1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexylmethyl 4-methylbenzenesulfonate
CAS No.:946530-10-5
Molecular Formula:C₃₃H₄₂N₄O₅S
Molecular Weight:606.786
Hs Code.:

Synonyms:(1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexylmethyl 4-methylbenzenesulfonate

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Chemical Property of (1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexylmethyl 4-methylbenzenesulfonate

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Technology Process of (1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexylmethyl 4-methylbenzenesulfonate

There total 12 articles about (1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexylmethyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 946530-07-0
(1r,4r)-4-(hydroxymethyl)-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cyclohexanecarboxamide

: 98-59-9
p-toluenesulfonyl chloride

: 946530-10-5
(1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexylmethyl 4-methylbenzenesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 48h; Inert atmosphere;

Reference yield:

: 5221-37-4
2-chloro-N-pyridin-2-ylacetamide

: 946530-10-5
(1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexylmethyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

1.2: 3 h / 80 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

2.2: 0.5 h / 0 °C

3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C

5.1: triethylamine / dichloromethane / 48 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 504-29-0
2-aminopyridine

: 946530-10-5
(1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexylmethyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

2.2: 3 h / 80 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

3.2: 0.5 h / 0 °C

4.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C

6.1: triethylamine / dichloromethane / 48 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;