4-Chloro-6-(3,4-dimethyl-phenyl)-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide

Base Information

Chemical Name:4-Chloro-6-(3,4-dimethyl-phenyl)-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide
CAS No.:78296-66-9
Molecular Formula:C₁₅H₁₃ClN₆O
Molecular Weight:328.761
Hs Code.:

Synonyms:4-Chloro-6-(3,4-dimethyl-phenyl)-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Chloro-6-(3,4-dimethyl-phenyl)-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide

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Technology Process of 4-Chloro-6-(3,4-dimethyl-phenyl)-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide

There total 7 articles about 4-Chloro-6-(3,4-dimethyl-phenyl)-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4418-61-5
5-aminotetrazole

: 4-Chloro-6-(3,4-dimethyl-phenyl)-pyridine-2-carbonyl chloride

: 78296-66-9
4-Chloro-6-(3,4-dimethyl-phenyl)-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Yield given;
DOI:10.1021/jm00364a026

Reference yield:

: 4-Chloro-2-(3,4-dimethyl-phenyl)-pyridine

: 78296-66-9
4-Chloro-6-(3,4-dimethyl-phenyl)-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 30percent aq. H₂O₂ / acetic acid / 20 h / 80 °C

2: 1.) Me₂SO₄ / 1.) 80-90 deg C, 2 h, 2.) dioxane, H₂O, RT, 30 min

3: 5 M aq. HCl / 11 h / Heating

4: SOCl₂ / 1 h / Heating

5: Et₃N / dimethylformamide / 2 h / 80 °C

With hydrogenchloride; thionyl chloride; dihydrogen peroxide; triethylamine; dimethyl sulfate; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00364a026

Reference yield:

: 4-Chloro-2-(3,4-dimethyl-phenyl)-pyridine 1-oxide

: 78296-66-9
4-Chloro-6-(3,4-dimethyl-phenyl)-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Me₂SO₄ / 1.) 80-90 deg C, 2 h, 2.) dioxane, H₂O, RT, 30 min

2: 5 M aq. HCl / 11 h / Heating

3: SOCl₂ / 1 h / Heating

4: Et₃N / dimethylformamide / 2 h / 80 °C

With hydrogenchloride; thionyl chloride; triethylamine; dimethyl sulfate; In N,N-dimethyl-formamide;
DOI:10.1021/jm00364a026