(E)-3-{4-[(3aR,4S,6S,6aR)-6-(1-benzenesulfonyl-1-nitroethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yloxy]-3-(4-methoxybenzyloxy)-phenyl}-2-methylacrylic acid

Base Information

Chemical Name:(E)-3-{4-[(3aR,4S,6S,6aR)-6-(1-benzenesulfonyl-1-nitroethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yloxy]-3-(4-methoxybenzyloxy)-phenyl}-2-methylacrylic acid
CAS No.:419572-63-7
Molecular Formula:C₃₃H₃₅NO₁₂S
Molecular Weight:669.706
Hs Code.:

(E)-3-{4-[(3aR,4S,6S,6aR)-6-(1-benzenesulfonyl-1-nitroethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yloxy]-3-(4-methoxybenzyloxy)-phenyl}-2-methylacrylic acid

Synonyms:(E)-3-{4-[(3aR,4S,6S,6aR)-6-(1-benzenesulfonyl-1-nitroethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yloxy]-3-(4-methoxybenzyloxy)-phenyl}-2-methylacrylic acid

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Chemical Property of (E)-3-{4-[(3aR,4S,6S,6aR)-6-(1-benzenesulfonyl-1-nitroethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yloxy]-3-(4-methoxybenzyloxy)-phenyl}-2-methylacrylic acid

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Technology Process of (E)-3-{4-[(3aR,4S,6S,6aR)-6-(1-benzenesulfonyl-1-nitroethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yloxy]-3-(4-methoxybenzyloxy)-phenyl}-2-methylacrylic acid

There total 6 articles about (E)-3-{4-[(3aR,4S,6S,6aR)-6-(1-benzenesulfonyl-1-nitroethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yloxy]-3-(4-methoxybenzyloxy)-phenyl}-2-methylacrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 419572-66-0
(E)-3-[4-[(3aR,4S,6S,6aS)-6-(1-Benzenesulfonyl-1-nitro-ethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yloxy]-3-(4-methoxy-benzyloxy)-phenyl]-2-methyl-acrylic acid ethyl ester

: 419572-63-7
(E)-3-{4-[(3aR,4S,6S,6aR)-6-(1-benzenesulfonyl-1-nitroethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yloxy]-3-(4-methoxybenzyloxy)-phenyl}-2-methylacrylic acid

Guidance literature:: With lithium hydroxide; In methanol; at 40 ℃; for 1h;
DOI:10.1002/1521-3765(20020104)8:1<293::AID-CHEM293>3.0.CO;2-L

Reference yield:

: 263887-24-7
4-hydroxy-3-(4-methoxyphenylmethoxy)benzaldehyde

: 419572-63-7
(E)-3-{4-[(3aR,4S,6S,6aR)-6-(1-benzenesulfonyl-1-nitroethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yloxy]-3-(4-methoxybenzyloxy)-phenyl}-2-methylacrylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / (1S,2S)-chx(o-NHCO-C₆H₄-PPh₂)2; Et₃N / [Pd₂dba3]*CHCl₃ / tetrahydrofuran / 1.5 h / 50 °C

2: 98 percent / N-methylmorpholine-N-oxide; aq. OsO₄ / CH₂Cl₂ / 20 °C

3: 100 percent / CH₂Cl₂ / 50 °C

4: 94 percent / p-TsOH / acetone / 4 h / 20 °C

5: 100 percent / aq. LiOH / methanol / 1 h / 40 °C

With lithium hydroxide; osmium(VIII) oxide; (1S,2S)-chx(o-NHCO-C₆H₄-PPh₂)2; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; acetone; 3: Wittig reaction;
DOI:10.1002/1521-3765(20020104)8:1<293::AID-CHEM293>3.0.CO;2-L

Reference yield:

: benzoic (2SR,5SR)-5-(1-benzenesulfonyl-1-nitroethyl)-2,5-dihydrofuran-2-yl ester

: 419572-63-7
(E)-3-{4-[(3aR,4S,6S,6aR)-6-(1-benzenesulfonyl-1-nitroethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yloxy]-3-(4-methoxybenzyloxy)-phenyl}-2-methylacrylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / (1S,2S)-chx(o-NHCO-C₆H₄-PPh₂)2; Et₃N / [Pd₂dba3]*CHCl₃ / tetrahydrofuran / 1.5 h / 50 °C

2: 98 percent / N-methylmorpholine-N-oxide; aq. OsO₄ / CH₂Cl₂ / 20 °C

3: 100 percent / CH₂Cl₂ / 50 °C

4: 94 percent / p-TsOH / acetone / 4 h / 20 °C

5: 100 percent / aq. LiOH / methanol / 1 h / 40 °C

With lithium hydroxide; osmium(VIII) oxide; (1S,2S)-chx(o-NHCO-C₆H₄-PPh₂)2; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; acetone; 3: Wittig reaction;
DOI:10.1002/1521-3765(20020104)8:1<293::AID-CHEM293>3.0.CO;2-L