methyl 2-acetamido-5-cyclohexylidenepentanoate

Base Information

• Chemical Name: methyl 2-acetamido-5-cyclohexylidenepentanoate
• CAS No.: 1520942-73-7
• Molecular Formula: C₁₄H₂₃NO₃
• Molecular Weight: 253.342
• Mol file: 1520942-73-7.mol

Synonyms:methyl 2-acetamido-5-cyclohexylidenepentanoate

Chemical Property of methyl 2-acetamido-5-cyclohexylidenepentanoate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methyl 2-acetamido-5-cyclohexylidenepentanoate

There total 2 articles about methyl 2-acetamido-5-cyclohexylidenepentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(±)-methyl 2-acetamidohex-5-enoate (193223-81-3) + methylenecyclohexane (1192-37-6) → C13H21NO3 (1520942-71-5) + methyl 2-acetamido-5-cyclohexylidenepentanoate (1520942-73-7)

Guidance literature:

With Hoveyda-Grubbs catalyst second generation; In dichloromethane; at 100 ℃; for 4h; Microwave irradiation; Inert atmosphere;

DOI:10.1055/s-0033-1338527

Reference yield:

(±)-2-acetamidohex-5-enoic acid (141943-64-8) → methyl 2-acetamido-5-cyclohexylidenepentanoate (1520942-73-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 18 h / 20 °C / pH 2

2: Hoveyda-Grubbs catalyst second generation / dichloromethane / 4 h / 100 °C / Microwave irradiation; Inert atmosphere

With hydrogenchloride; Hoveyda-Grubbs catalyst second generation; In dichloromethane;

DOI:10.1055/s-0033-1338527

Reference yield:

C13H21NO3 (1520942-71-5) + methyl 2-acetamido-5-cyclohexylidenepentanoate (1520942-73-7) → C13H21NO3 (1520942-75-9) + C14H23NO3 (1520942-76-0)

Guidance literature:

With trifluorormethanesulfonic acid; In chloroform; at 50 ℃; for 1h; Microwave irradiation; Inert atmosphere;

DOI:10.1055/s-0033-1338527

upstream raw materials:

(±)-methyl 2-acetamidohex-5-enoate

methylenecyclohexane

(±)-2-acetamidohex-5-enoic acid

Downstream raw materials:

C₁₃H₂₁NO₃

C₁₄H₂₃NO₃

Refernces