2,5-dichloro-3,4-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide

Base Information

Chemical Name:2,5-dichloro-3,4-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide
CAS No.:1225208-52-5
Molecular Formula:C₂₉H₃₂Cl₂N₂O₅
Molecular Weight:559.489
Hs Code.:

Synonyms:2,5-dichloro-3,4-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide

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Chemical Property of 2,5-dichloro-3,4-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide

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Technology Process of 2,5-dichloro-3,4-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide

There total 4 articles about 2,5-dichloro-3,4-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 2,5-dichloro-3,4-bis((4-methoxybenzyl)oxy)benzoic acid

: 1225208-52-5
2,5-dichloro-3,4-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide

Guidance literature:: 2,5-dichloro-3,4-bis((4-methoxybenzyl)oxy)benzoic acid; With methanesulfonyl chloride; triethylamine; In N,N-dimethyl acetamide; at -15 ℃; for 1.16667h;

1-(2-aminoethyl)pyrrolidine; In N,N-dimethyl acetamide; at -15 ℃; for 1h;

Reference yield:

: 132496-71-0
4-methoxybenzyl 2,5-dichloro-3,4-bis((4-methoxybenzyl)oxy)benzoate

: 1225208-52-5
2,5-dichloro-3,4-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 70 °C

2.1: triethylamine; methanesulfonyl chloride / N,N-dimethyl acetamide / 1.17 h / -15 °C

2.2: 1 h / -15 °C

With water; methanesulfonyl chloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl acetamide;

Reference yield:

: 108098-45-9
2,5-dichloro-3,4-dihydroxybenzoic acid

: 1225208-52-5
2,5-dichloro-3,4-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 1 h / 70 °C

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 70 °C

3.1: triethylamine; methanesulfonyl chloride / N,N-dimethyl acetamide / 1.17 h / -15 °C

3.2: 1 h / -15 °C

With water; potassium carbonate; methanesulfonyl chloride; triethylamine; potassium iodide; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;