N-(3-Benzyloxy-4-methoxy)-benzyl-N-tosylaminoacetaldehyd-dimethylacetal

Base Information

• Chemical Name: N-(3-Benzyloxy-4-methoxy)-benzyl-N-tosylaminoacetaldehyd-dimethylacetal
• CAS No.: 150982-71-1
• Molecular Formula: C₂₆H₃₁NO₆S
• Molecular Weight: 485.601
• Mol file: 150982-71-1.mol

Synonyms:N-(3-Benzyloxy-4-methoxy)-benzyl-N-tosylaminoacetaldehyd-dimethylacetal

Chemical Property of N-(3-Benzyloxy-4-methoxy)-benzyl-N-tosylaminoacetaldehyd-dimethylacetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-Benzyloxy-4-methoxy)-benzyl-N-tosylaminoacetaldehyd-dimethylacetal

There total 2 articles about N-(3-Benzyloxy-4-methoxy)-benzyl-N-tosylaminoacetaldehyd-dimethylacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(3-Benzyloxy-4-methoxy)-benzyliden-aminoacetaldehyd-dimethylacetal (41462-21-9) → N-(3-Benzyloxy-4-methoxy)-benzyl-N-tosylaminoacetaldehyd-dimethylacetal (150982-71-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / NaBH₄ / methanol / 4 h / Ambient temperature

2: 1) NaOH, 4N>HSO₄ / 1) CH₂Cl₂, r.t., 5 min, 2) CH₂Cl₂, r.t., 1 h

With sodium hydroxide; sodium tetrahydroborate; tetra(n-butyl)ammonium hydrogensulfate; In methanol;

DOI:10.1002/ardp.19933260502

Reference yield:

N-(3-Benzyloxy-4-methoxy)-benzylaminoacetaldehyd-dimethylacetal (150982-70-0) + p-toluenesulfonyl chloride (98-59-9) → N-(3-Benzyloxy-4-methoxy)-benzyl-N-tosylaminoacetaldehyd-dimethylacetal (150982-71-1)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; Yield given. Multistep reaction; 1) CH₂Cl₂, r.t., 5 min, 2) CH₂Cl₂, r.t., 1 h;

DOI:10.1002/ardp.19933260502

Reference yield: 79.0%

N-(3-Benzyloxy-4-methoxy)-benzyl-N-tosylaminoacetaldehyd-dimethylacetal (150982-71-1) → 7-benzyloxy-6-methoxyisoquinoline (70592-30-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; 1) r.t., 1 h, 2) 60 deg C, 1 h, 3) reflux, 2 h;

DOI:10.1002/ardp.19933260502

upstream raw materials:

N-(3-Benzyloxy-4-methoxy)-benzylaminoacetaldehyd-dimethylacetal

p-toluenesulfonyl chloride

N-(3-Benzyloxy-4-methoxy)-benzyliden-aminoacetaldehyd-dimethylacetal

Downstream raw materials:

7-benzyloxy-6-methoxyisoquinoline