4-(3-chloro-4-fluoroanilino)-7-methoxy-6-[(piperidin-4-yl)oxy]quinazoline

Base Information

Chemical Name:4-(3-chloro-4-fluoroanilino)-7-methoxy-6-[(piperidin-4-yl)oxy]quinazoline
CAS No.:609767-48-8
Molecular Formula:C₂₀H₂₀ClFN₄O₂
Molecular Weight:402.856
Hs Code.:

Synonyms:4-(3-chloro-4-fluoroanilino)-7-methoxy-6-[(piperidin-4-yl)oxy]quinazoline

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Chemical Property of 4-(3-chloro-4-fluoroanilino)-7-methoxy-6-[(piperidin-4-yl)oxy]quinazoline

Chemical Property:

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Technology Process of 4-(3-chloro-4-fluoroanilino)-7-methoxy-6-[(piperidin-4-yl)oxy]quinazoline

There total 5 articles about 4-(3-chloro-4-fluoroanilino)-7-methoxy-6-[(piperidin-4-yl)oxy]quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 4-[(3-chloro-4-fluoro-phenyl)amino]-6-(1-ethyloxycarbonyl-piperidin-4-yloxy)-7-methoxy-quinazoline

: 609767-48-8
4-(3-chloro-4-fluoroanilino)-7-methoxy-6-[(piperidin-4-yl)oxy]quinazoline

Guidance literature:: With potassium hydroxide; isopropyl alcohol; for 48h; Heating / reflux;

Reference yield: 76.0%

: 609767-43-3
6-[(1-tert-butoxycarbonylpiperidin-4-yl)oxy]-4-(3-chloro-4-fluoroanilino)-7-methoxyquinazoline

: 609767-48-8
4-(3-chloro-4-fluoroanilino)-7-methoxy-6-[(piperidin-4-yl)oxy]quinazoline

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ml400146c

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 609767-48-8
4-(3-chloro-4-fluoroanilino)-7-methoxy-6-[(piperidin-4-yl)oxy]quinazoline

Guidance literature:: Multi-step reaction with 4 steps

1: ammonia / methanol / 1 h / 10 °C / Inert atmosphere

2: triphenylphosphine; di-tert-butyl-diazodicarboxylate / dichloromethane / 16 h / 5 - 20 °C / Inert atmosphere

3: hydrogenchloride / isopropyl alcohol / 1 h / 80 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; di-tert-butyl-diazodicarboxylate; ammonia; triphenylphosphine; trifluoroacetic acid; In methanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/ml400146c