1-<(Benzyloxy)methyl>-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-3-(methoxymethyl)-5-(trifluoromethanesulfonyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

Base Information

Chemical Name:1-<(Benzyloxy)methyl>-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-3-(methoxymethyl)-5-(trifluoromethanesulfonyl)pyrrolo<2,3-d>pyrimidine-2,4-dione
CAS No.:159626-10-5
Molecular Formula:C₃₈H₃₆F₃N₃O₁₂S
Molecular Weight:815.778
Hs Code.:

1-<(Benzyloxy)methyl>-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-3-(methoxymethyl)-5-(trifluoromethanesulfonyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

Synonyms:1-<(Benzyloxy)methyl>-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-3-(methoxymethyl)-5-(trifluoromethanesulfonyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

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Chemical Property of 1-<(Benzyloxy)methyl>-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-3-(methoxymethyl)-5-(trifluoromethanesulfonyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

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Technology Process of 1-<(Benzyloxy)methyl>-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-3-(methoxymethyl)-5-(trifluoromethanesulfonyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

There total 3 articles about 1-<(Benzyloxy)methyl>-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-3-(methoxymethyl)-5-(trifluoromethanesulfonyl)pyrrolo<2,3-d>pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.3%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1-<(Benzyloxy)methyl>-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-3-(methoxymethyl)pyrrolo<2,3-d>pyrimidine-2,4,5-trione

: 159626-10-5
1-<(Benzyloxy)methyl>-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-3-(methoxymethyl)-5-(trifluoromethanesulfonyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

Guidance literature:: With 2,4,6-trimethyl-pyridine; In dichloromethane; at -78 ℃; for 0.25h;
DOI:10.1021/jo00121a027

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 159626-09-2
C₃₇H₃₇N₃O₁₀

: 159626-10-5
1-<(Benzyloxy)methyl>-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-3-(methoxymethyl)-5-(trifluoromethanesulfonyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

Guidance literature:: With 2,3,5-trimethyl-pyridine; In dichloromethane; at -78 ℃; Yield given;
DOI:10.1021/jo00102a011

Reference yield:

: 5-Acetoxy-1-<(benzyloxy)methyl>-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-D-erythro-pentofuranosyl>-3-(methoxymethyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

: 159626-10-5
1-<(Benzyloxy)methyl>-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-3-(methoxymethyl)-5-(trifluoromethanesulfonyl)pyrrolo<2,3-d>pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: NaHCO₃ / tetrahydrofuran; methanol / 0.83 h / 25 °C

2: 95.3 percent / 2,4,6-collidine / CH₂Cl₂ / 0.25 h / -78 °C

With 2,4,6-trimethyl-pyridine; sodium hydrogencarbonate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo00121a027