1-benzyl-4-[2-(benzyloxy)-6-bromophenoxymethyl]-1,2,3,6-tetrahydropyridine

Base Information

Chemical Name:1-benzyl-4-[2-(benzyloxy)-6-bromophenoxymethyl]-1,2,3,6-tetrahydropyridine
CAS No.:1372147-73-3
Molecular Formula:C₂₆H₂₆BrNO₂
Molecular Weight:464.402
Hs Code.:

Synonyms:1-benzyl-4-[2-(benzyloxy)-6-bromophenoxymethyl]-1,2,3,6-tetrahydropyridine

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Chemical Property of 1-benzyl-4-[2-(benzyloxy)-6-bromophenoxymethyl]-1,2,3,6-tetrahydropyridine

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Technology Process of 1-benzyl-4-[2-(benzyloxy)-6-bromophenoxymethyl]-1,2,3,6-tetrahydropyridine

There total 5 articles about 1-benzyl-4-[2-(benzyloxy)-6-bromophenoxymethyl]-1,2,3,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1372147-65-3
1-benzyl-4-[2-(benzyloxy)-6-bromophenoxymethyl]pyridinium bromide

: 1372147-73-3
1-benzyl-4-[2-(benzyloxy)-6-bromophenoxymethyl]-1,2,3,6-tetrahydropyridine

Guidance literature:: 1-benzyl-4-[2-(benzyloxy)-6-bromophenoxymethyl]pyridinium bromide; With sodium tetrahydroborate; In methanol; at -5 - 20 ℃; for 2h;

With ammonium chloride; In water; ethyl acetate;
DOI:10.1016/j.tetlet.2012.03.005

Reference yield:

: 586-95-8
pyridine-4-methanol

: 1372147-73-3
1-benzyl-4-[2-(benzyloxy)-6-bromophenoxymethyl]-1,2,3,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.5 h / 60 °C / Cooling with ice

1.2: 2 h / 100 °C

2.1: acetone / 18 h / Reflux

3.1: sodium tetrahydroborate / methanol / 2 h / -5 - 20 °C

With sodium tetrahydroborate; sodium hydride; In 1-methyl-pyrrolidin-2-one; methanol; acetone; mineral oil;
DOI:10.1016/j.tetlet.2012.03.005

Reference yield:

: 156682-53-0
3-bromo-2-fluoro-phenol

: 1372147-73-3
1-benzyl-4-[2-(benzyloxy)-6-bromophenoxymethyl]-1,2,3,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 4 h / Reflux

2.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.5 h / 60 °C / Cooling with ice

2.2: 2 h / 100 °C

3.1: acetone / 18 h / Reflux

4.1: sodium tetrahydroborate / methanol / 2 h / -5 - 20 °C

With sodium tetrahydroborate; sodium hydride; potassium carbonate; In 1-methyl-pyrrolidin-2-one; methanol; acetone; mineral oil;
DOI:10.1016/j.tetlet.2012.03.005