N-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-y l)phenyl)-4-toluenesulfonamide

Base Information

Chemical Name:N-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-y l)phenyl)-4-toluenesulfonamide
CAS No.:1477503-77-7
Molecular Formula:C₂₁H₁₅ClF₃N₃O₂S
Molecular Weight:465.883
Hs Code.:

Synonyms:N-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-y l)phenyl)-4-toluenesulfonamide

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Chemical Property of N-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-y l)phenyl)-4-toluenesulfonamide

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Technology Process of N-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-y l)phenyl)-4-toluenesulfonamide

There total 5 articles about N-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-y l)phenyl)-4-toluenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 860785-05-3
C₁₄H₉ClF₃N₃

: 98-59-9
p-toluenesulfonyl chloride

: 1477503-77-7
N-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-y l)phenyl)-4-toluenesulfonamide

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 3h; Cooling with ice;
DOI:10.1007/s12272-013-0253-9

Reference yield:

: 2227-64-7
3'-nitro-2-bromoacetophenone

: 1477503-77-7
N-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-y l)phenyl)-4-toluenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: N,N'-ditosylhydrazine; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 °C

2: copper(II) bis(trifluoromethanesulfonate) / 1,2-dichloro-ethane / 80 °C

3: tin(ll) chloride; hydrogenchloride / ethanol / Reflux

4: triethylamine; dmap / dichloromethane / 3 h / 20 °C / Cooling with ice

With hydrogenchloride; dmap; N,N'-ditosylhydrazine; copper(II) bis(trifluoromethanesulfonate); 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; tin(ll) chloride; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1007/s12272-013-0253-9

Reference yield:

: 121-89-1
3-Nitroacetophenone

: 1477503-77-7
N-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-y l)phenyl)-4-toluenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridinium hydrobromide perbromide / acetic acid / Reflux

2: N,N'-ditosylhydrazine; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 °C

3: copper(II) bis(trifluoromethanesulfonate) / 1,2-dichloro-ethane / 80 °C

4: tin(ll) chloride; hydrogenchloride / ethanol / Reflux

5: triethylamine; dmap / dichloromethane / 3 h / 20 °C / Cooling with ice

With hydrogenchloride; dmap; N,N'-ditosylhydrazine; pyridinium hydrobromide perbromide; copper(II) bis(trifluoromethanesulfonate); 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; tin(ll) chloride; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; 1,2-dichloro-ethane;
DOI:10.1007/s12272-013-0253-9