ethyl 4-((7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-brorno-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate

Base Information

Chemical Name:ethyl 4-((7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-brorno-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate
CAS No.:1260105-99-4
Molecular Formula:C₃₉H₅₆BrN₅O₄Si₂
Molecular Weight:794.98
Hs Code.:

ethyl 4-((7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-brorno-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate

Synonyms:ethyl 4-((7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-brorno-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate

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Chemical Property of ethyl 4-((7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-brorno-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate

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Technology Process of ethyl 4-((7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-brorno-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate

There total 13 articles about ethyl 4-((7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-brorno-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1260105-98-3
ethyl 4-((7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate

: 1260105-99-4
ethyl 4-((7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-brorno-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate

Guidance literature:: With N-Bromosuccinimide; In acetonitrile; at 20 ℃; for 18h;

Reference yield:

: 218779-74-9
ethyl 4-(2-(tert-butoxy)-2-oxoethylidene)cyclohexanecarboxylate

: 1260105-99-4
ethyl 4-((7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-brorno-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 12 steps

1.1: hydrogen / 5% Pd(II)/C(eggshell) / ethyl acetate / 18 h / Inert atmosphere; Sealed tube

2.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

3.1: tetrahydrofuran / 18 h / 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: 18 h / -78 - 20 °C / Inert atmosphere

5.1: 18 h / 100 °C / Neat (no solvent)

6.1: trichlorophosphate; N,N-dimethyl-aniline / 18 h / 20 °C

6.2: 0 °C

7.1: ammonia / methanol / 4 h / 90 °C / Microwave irradiation

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

9.1: N-iodo-succinimide / acetonitrile / 18 h / 20 °C

10.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 18 h / 100 °C / Microwave irradiation; Inert atmosphere; Sealed tube

11.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.33 h / 140 °C / Inert atmosphere; Microwave irradiation; Sealed tube

12.1: N-Bromosuccinimide / acetonitrile / 18 h / 20 °C

With hydrogenchloride; potassium phosphate; N-Bromosuccinimide; N-iodo-succinimide; ammonia; hydrogen; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5% Pd(II)/C(eggshell); In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; acetonitrile;

Reference yield:

: 218779-77-2
2-(4-(ethoxycarbonyl)cyclohexyl)acetic acid

: 1260105-99-4
ethyl 4-((7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-brorno-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: tetrahydrofuran / 18 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 18 h / -78 - 20 °C / Inert atmosphere

3.1: 18 h / 100 °C / Neat (no solvent)

4.1: trichlorophosphate; N,N-dimethyl-aniline / 18 h / 20 °C

4.2: 0 °C

5.1: ammonia / methanol / 4 h / 90 °C / Microwave irradiation

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

7.1: N-iodo-succinimide / acetonitrile / 18 h / 20 °C

8.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 18 h / 100 °C / Microwave irradiation; Inert atmosphere; Sealed tube

9.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.33 h / 140 °C / Inert atmosphere; Microwave irradiation; Sealed tube

10.1: N-Bromosuccinimide / acetonitrile / 18 h / 20 °C

With potassium phosphate; N-Bromosuccinimide; N-iodo-succinimide; ammonia; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetonitrile;