(±)-(2E)-ethylthio-2-ethylidene-5-(p-toluenesulfonyl)oxy-3-(benzyloxymethyl)pentanoate

Base Information

Chemical Name:(±)-(2E)-ethylthio-2-ethylidene-5-(p-toluenesulfonyl)oxy-3-(benzyloxymethyl)pentanoate
CAS No.:1365839-67-3
Molecular Formula:C₂₄H₃₀O₅S₂
Molecular Weight:462.631
Hs Code.:

Synonyms:(±)-(2E)-ethylthio-2-ethylidene-5-(p-toluenesulfonyl)oxy-3-(benzyloxymethyl)pentanoate

Suppliers and Price of (±)-(2E)-ethylthio-2-ethylidene-5-(p-toluenesulfonyl)oxy-3-(benzyloxymethyl)pentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (±)-(2E)-ethylthio-2-ethylidene-5-(p-toluenesulfonyl)oxy-3-(benzyloxymethyl)pentanoate

Chemical Property:

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Technology Process of (±)-(2E)-ethylthio-2-ethylidene-5-(p-toluenesulfonyl)oxy-3-(benzyloxymethyl)pentanoate

There total 6 articles about (±)-(2E)-ethylthio-2-ethylidene-5-(p-toluenesulfonyl)oxy-3-(benzyloxymethyl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1365839-78-6
(±)-(2E)-ethylthio-2-ethylidene-5-hydroxy-3-(benzyloxymethyl)pentanoate

: 98-59-9
p-toluenesulfonyl chloride

: 1365839-67-3
(±)-(2E)-ethylthio-2-ethylidene-5-(p-toluenesulfonyl)oxy-3-(benzyloxymethyl)pentanoate

Guidance literature:: With trimethylamine hydrochloride; triethylamine; In dichloromethane;
DOI:10.1016/j.tetlet.2012.01.110

Reference yield:

: C₂₁H₂₁NO₄

: 1365839-67-3
(±)-(2E)-ethylthio-2-ethylidene-5-(p-toluenesulfonyl)oxy-3-(benzyloxymethyl)pentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium diisopropyl amide / tetrahydrofuran / -78 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran

3: sodium tetrahydroborate; cerium(III) chloride heptahydrate / tetrahydrofuran; methanol / -50 °C

4: trimethylamine hydrochloride; triethylamine / dichloromethane

With sodium tetrahydroborate; cerium(III) chloride heptahydrate; trimethylamine hydrochloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; 1: Michael condensation;
DOI:10.1016/j.tetlet.2012.01.110

Reference yield:

: 1365839-65-1
C₂₇H₃₁NO₅S

: 1365839-67-3
(±)-(2E)-ethylthio-2-ethylidene-5-(p-toluenesulfonyl)oxy-3-(benzyloxymethyl)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran

2: sodium tetrahydroborate; cerium(III) chloride heptahydrate / tetrahydrofuran; methanol / -50 °C

3: trimethylamine hydrochloride; triethylamine / dichloromethane

With sodium tetrahydroborate; cerium(III) chloride heptahydrate; trimethylamine hydrochloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.tetlet.2012.01.110