N⁽¹⁾-(4-butylphenyl)-N⁽²⁾-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide

Base Information

• Chemical Name: N⁽¹⁾-(4-butylphenyl)-N⁽²⁾-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide
• CAS No.: 1361226-02-9
• Molecular Formula: C₃₀H₃₄N₂O₄
• Molecular Weight: 486.611
• Mol file: 1361226-02-9.mol

Synonyms:N⁽¹⁾-(4-butylphenyl)-N⁽²⁾-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide

Chemical Property of N⁽¹⁾-(4-butylphenyl)-N⁽²⁾-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁽¹⁾-(4-butylphenyl)-N⁽²⁾-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide

There total 5 articles about N⁽¹⁾-(4-butylphenyl)-N⁽²⁾-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3,4-dihydro-2H-pyran (110-87-2) + N(1)-(4-butylphenyl)-N(2)-(3-(hydroxymethyl)phenyl)phthalamide (1253889-38-1) → N(1)-(4-butylphenyl)-N(2)-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide (1361226-02-9)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201102018

Reference yield:

phthalic anhydride (85-44-9) → N(1)-(4-butylphenyl)-N(2)-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide (1361226-02-9)

Guidance literature:

Multi-step reaction with 4 steps

1: chloroform / 3 h / Inert atmosphere; Reflux

2: triethylamine; trifluoroacetic anhydride / 1,4-dioxane / 0 - 20 °C / Inert atmosphere

3: tetrahydrofuran / 20 °C / Inert atmosphere

4: toluene-4-sulfonic acid / dichloromethane / 20 °C / Inert atmosphere

With toluene-4-sulfonic acid; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform;

DOI:10.1002/chem.201102018

Reference yield:

2-(4-butylphenylcarbamoyl)benzoic acid (19543-72-7) → N(1)-(4-butylphenyl)-N(2)-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide (1361226-02-9)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine; trifluoroacetic anhydride / 1,4-dioxane / 0 - 20 °C / Inert atmosphere

2: tetrahydrofuran / 20 °C / Inert atmosphere

3: toluene-4-sulfonic acid / dichloromethane / 20 °C / Inert atmosphere

With toluene-4-sulfonic acid; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

DOI:10.1002/chem.201102018

upstream raw materials:

3,4-dihydro-2H-pyran

N⁽¹⁾-(4-butylphenyl)-N⁽²⁾-(3-(hydroxymethyl)phenyl)phthalamide

phthalic anhydride

2-(4-butylphenylcarbamoyl)benzoic acid

Downstream raw materials:

N⁽¹⁾-(4-butylphenyl)-N⁽¹⁾,N⁽²⁾-dimethyl-N⁽²⁾-(3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)phthalamide