1,3-Benzodioxole-5-methanamine, .alpha.-methyl-, (.alpha.S)-

Base Information

• Chemical Name: 1,3-Benzodioxole-5-methanamine, .alpha.-methyl-, (.alpha.S)-
• CAS No.: 210488-52-1
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.192
• Mol file: 210488-52-1.mol

Synonyms:(S)-1-(benzo[d][1,3]dioxol-5-yl)ethan-1-amine

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of 1,3-Benzodioxole-5-methanamine, .alpha.-methyl-, (.alpha.S)-

Chemical Property:

• Boiling Point: 260.9±29.0 °C(Predicted)
• PKA: 9.46±0.40(Predicted)
• Density: 1.198±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-Benzodioxole-5-methanamine, .alpha.-methyl-, (.alpha.S)-

There total 6 articles about 1,3-Benzodioxole-5-methanamine, .alpha.-methyl-, (.alpha.S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.84%

(RS)-N-((S)-1-(benzo[d][1,3]dioxol-5-yl)ethyl)-2-methylpropane-2-sulfinamide → (S)-1-(benzo[d][1,3]dioxol-5-yl)ethan-1-amine (210488-52-1)

Guidance literature:

With thionyl chloride; In methanol; at 0 - 20 ℃; for 1.25h;

Reference yield: 92.84%

(R)-N-((S)-1-(benzo[d][1,3]dioxol-5-yl)ethyl)-2-methylpropane-2-sulfinamide → (S)-1-(benzo[d][1,3]dioxol-5-yl)ethan-1-amine (210488-52-1)

Guidance literature:

With thionyl chloride; In methanol; at 0 - 20 ℃; for 1h;

Reference yield: 69.0%

(S)-2-{(S)-[1-(benzo[1,3]dioxol-5-yl)ethyl]amino}-3-methylbutan-1-ol (1010385-15-5) → (S)-1-(benzo[d][1,3]dioxol-5-yl)ethan-1-amine (210488-52-1)

Guidance literature:

(S)-2-{(S)-[1-(benzo[1,3]dioxol-5-yl)ethyl]amino}-3-methylbutan-1-ol; With periodic acid; methylamine; In methanol; water; at 20 ℃; for 3h;

With hydrogenchloride; In methanol; for 0.5h; Further stages.;

DOI:10.1016/j.tetasy.2007.11.014

upstream raw materials:

(S)-2-{(S)-[1-(benzo[1,3]dioxol-5-yl)ethyl]amino}-3-methylbutan-1-ol

1-(benzo[d][1,3]dioxol-6-yl)ethanone

Refernces

• 1、 -. "GLYCOSIDASE INHIBITORS". . . Retrieved 2017/09/15.
• 2、 -. "GLYCOSIDASE INHIBITORS". . . Retrieved 2016/03/22.