2-(4-fluorophenyl)-6-methoxy-N-(3,4,5-trimethoxyphenyl)benzo[b]thiophen-3-amine

Base Information

• Chemical Name: 2-(4-fluorophenyl)-6-methoxy-N-(3,4,5-trimethoxyphenyl)benzo[b]thiophen-3-amine
• CAS No.: 1050682-82-0
• Molecular Formula: C₂₄H₂₂FNO₄S
• Molecular Weight: 439.507
• Mol file: 1050682-82-0.mol

Synonyms:2-(4-fluorophenyl)-6-methoxy-N-(3,4,5-trimethoxyphenyl)benzo[b]thiophen-3-amine

Chemical Property of 2-(4-fluorophenyl)-6-methoxy-N-(3,4,5-trimethoxyphenyl)benzo[b]thiophen-3-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-fluorophenyl)-6-methoxy-N-(3,4,5-trimethoxyphenyl)benzo[b]thiophen-3-amine

There total 7 articles about 2-(4-fluorophenyl)-6-methoxy-N-(3,4,5-trimethoxyphenyl)benzo[b]thiophen-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-chloro-2-(4-fluorophenyl)-6-methoxybenzo[b]thiophene (1050682-27-3) + 3,4,5-Trimethoxyaniline (24313-88-0) → 2-(4-fluorophenyl)-6-methoxy-N-(3,4,5-trimethoxyphenyl)benzo[b]thiophen-3-amine (1050682-82-0)

Guidance literature:

With sodium t-butanolate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride; In toluene; at 100 ℃; for 4h;

DOI:10.1002/adsc.200700172

Reference yield: 69.0%

3 -bromo-2-(4-fluorophenyl)-6-methoxy-1-benzothiophene (847386-21-4) + 3,4,5-Trimethoxyaniline (24313-88-0) → 2-(4-fluorophenyl)-6-methoxy-N-(3,4,5-trimethoxyphenyl)benzo[b]thiophen-3-amine (1050682-82-0)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In toluene; at 100 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.bioorg.2021.104919

Reference yield:

2-(4-fluorophenyl)-6-methoxybenzo[b]thiophene (166975-72-0) → 2-(4-fluorophenyl)-6-methoxy-N-(3,4,5-trimethoxyphenyl)benzo[b]thiophen-3-amine (1050682-82-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide / tetrahydrofuran / 2 h / 0 - 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / toluene / 18 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In tetrahydrofuran; toluene;

DOI:10.1016/j.bioorg.2021.104919

upstream raw materials:

3-chloro-2-(4-fluorophenyl)-6-methoxybenzo[b]thiophene

3,4,5-Trimethoxyaniline

3 -bromo-2-(4-fluorophenyl)-6-methoxy-1-benzothiophene

2-(4-fluorophenyl)-6-methoxybenzo[b]thiophene