3,4-bis-(1-benzenesulfonyl-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

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Chemical Name:3,4-bis-(1-benzenesulfonyl-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester
CAS No.:1207173-02-1
Molecular Formula:C₃₆H₂₇N₃O₈S₂
Molecular Weight:693.758
Hs Code.:

Synonyms:3,4-bis-(1-benzenesulfonyl-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

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Chemical Property of 3,4-bis-(1-benzenesulfonyl-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

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Technology Process of 3,4-bis-(1-benzenesulfonyl-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

There total 7 articles about 3,4-bis-(1-benzenesulfonyl-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 870717-93-4
1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole

: 3-(1-benzenesulfonyl-1H-indol-3-yl)-4-bromo-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

: 1207173-02-1
3,4-bis-(1-benzenesulfonyl-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In ethanol; water; toluene; at 110 ℃; for 2h; Microwave irradiation;
DOI:10.1016/j.tet.2014.11.035

Reference yield: 54.0%

: 1207173-01-0
C₃₀H₂₂N₂O₄S₂

: 2166-14-5
1,2,4,5-tetrazine-3,6-dicarboxylic acid dimethyl ester

: 1207173-02-1
3,4-bis-(1-benzenesulfonyl-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

Guidance literature:: C₃₀H₂₂N₂O₄S₂; 1,2,4,5-tetrazine-3,6-dicarboxylic acid dimethyl ester; In toluene; Reflux;

With zinc; In acetic acid;
DOI:10.1016/j.tetlet.2009.11.085

Reference yield:

: 934-05-4
methyl 4-bromo-1H-pyrrole-2-carboxylate

: 1207173-02-1
3,4-bis-(1-benzenesulfonyl-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / dichloromethane / 20 °C

2.1: 1,4-diaza-bicyclo[2.2.2]octane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; ethanol; water / 2 h / 110 °C / Microwave irradiation

3.1: sodium dihydrogenphosphate; sodium chlorite / water; dimethyl sulfoxide

4.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 40 °C / Inert atmosphere

4.2: 24 h / 40 °C / Inert atmosphere

5.1: potassium hydroxide / N,N-dimethyl-formamide / 0.25 h

5.2: 20 °C / Darkness

6.1: 1,4-diaza-bicyclo[2.2.2]octane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; ethanol; water / 2 h / 110 °C / Microwave irradiation

With 1,4-diaza-bicyclo[2.2.2]octane; sodium chlorite; sodium dihydrogenphosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-carbonyldiimidazole; potassium hydroxide; trichlorophosphate; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 2.1: |Suzuki Coupling / 6.1: |Suzuki Coupling;
DOI:10.1016/j.tet.2014.11.035