3-[5-chloro-4-(4-fluoro-benzyloxy)-2-methyl-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide

Base Information

Chemical Name:3-[5-chloro-4-(4-fluoro-benzyloxy)-2-methyl-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide
CAS No.:1442452-05-2
Molecular Formula:C₂₂H₂₁ClFN₃O₄
Molecular Weight:445.878
Hs Code.:

Synonyms:3-[5-chloro-4-(4-fluoro-benzyloxy)-2-methyl-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide

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Chemical Property of 3-[5-chloro-4-(4-fluoro-benzyloxy)-2-methyl-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide

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Technology Process of 3-[5-chloro-4-(4-fluoro-benzyloxy)-2-methyl-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide

There total 6 articles about 3-[5-chloro-4-(4-fluoro-benzyloxy)-2-methyl-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1442452-04-1
3-[5-chloro-4-(4-fluoro-benzyloxy)-2-methyl-6-oxo-6H-pyrimidin-1-yl]-4-methyl-benzoic acid methyl ester

: 16645-06-0
N,N-dimethylhydroxylamine hydrochloride

: 1442452-05-2
3-[5-chloro-4-(4-fluoro-benzyloxy)-2-methyl-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide

Guidance literature:: 3-[5-chloro-4-(4-fluoro-benzyloxy)-2-methyl-6-oxo-6H-pyrimidin-1-yl]-4-methyl-benzoic acid methyl ester; With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 18h;

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 1h;

N,N-dimethylhydroxylamine hydrochloride; With triethylamine; for 18h;

Reference yield:

: 1442451-93-5
3-(4-hydroxy-2-methyl-6-oxo-6H-pyrimidin-1-yl)-4-methyl-benzoic acid methyl ester

: 1442452-05-2
3-[5-chloro-4-(4-fluoro-benzyloxy)-2-methyl-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 2 h / 60 °C

2.1: N-chloro-succinimide; dichloro-acetic acid / isopropyl alcohol / 3 h / 20 - 30 °C

3.1: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 2 h / 20 °C

4.1: sodium hydroxide / tetrahydrofuran / 18 h / 20 °C

4.2: 1 h / 20 °C

4.3: 18 h

With dichloro-acetic acid; N-chloro-succinimide; 18-crown-6 ether; potassium carbonate; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1442451-94-6
3-[4-(4-methoxy-benzyloxy)-2-methyl-6-oxo-6H-pyrimidin-1-yl]-4-methyl-benzoic acid methyl ester

: 1442452-05-2
3-[5-chloro-4-(4-fluoro-benzyloxy)-2-methyl-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-chloro-succinimide; dichloro-acetic acid / isopropyl alcohol / 3 h / 20 - 30 °C

2.1: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: sodium hydroxide / tetrahydrofuran / 18 h / 20 °C

3.2: 1 h / 20 °C

3.3: 18 h

With dichloro-acetic acid; N-chloro-succinimide; 18-crown-6 ether; potassium carbonate; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol;