3-[N-(tert-butyloxycarbonyl)-N-(3-chloroprop-2-en-1-yl)amino]-1-benzyloxy-4-iodoisoquinoline

Base Information

Chemical Name:3-[N-(tert-butyloxycarbonyl)-N-(3-chloroprop-2-en-1-yl)amino]-1-benzyloxy-4-iodoisoquinoline
CAS No.:577705-95-4
Molecular Formula:C₂₄H₂₄ClIN₂O₃
Molecular Weight:550.824
Hs Code.:

Synonyms:3-[N-(tert-butyloxycarbonyl)-N-(3-chloroprop-2-en-1-yl)amino]-1-benzyloxy-4-iodoisoquinoline

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Chemical Property of 3-[N-(tert-butyloxycarbonyl)-N-(3-chloroprop-2-en-1-yl)amino]-1-benzyloxy-4-iodoisoquinoline

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Technology Process of 3-[N-(tert-butyloxycarbonyl)-N-(3-chloroprop-2-en-1-yl)amino]-1-benzyloxy-4-iodoisoquinoline

There total 6 articles about 3-[N-(tert-butyloxycarbonyl)-N-(3-chloroprop-2-en-1-yl)amino]-1-benzyloxy-4-iodoisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 542-75-6
E/Z-1,3-Dichloropropene

: 577705-94-3
1-benzyloxy-3-(tert-butyloxycarbonyl)amino-4-iodoisoquinoline

: 577705-95-4
3-[N-(tert-butyloxycarbonyl)-N-(3-chloroprop-2-en-1-yl)amino]-1-benzyloxy-4-iodoisoquinoline

Guidance literature:: 1-benzyloxy-3-(tert-butyloxycarbonyl)amino-4-iodoisoquinoline; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

E/Z-1,3-Dichloropropene; With tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 25 ℃; for 3h;
DOI:10.1021/ol035000t

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 577705-95-4
3-[N-(tert-butyloxycarbonyl)-N-(3-chloroprop-2-en-1-yl)amino]-1-benzyloxy-4-iodoisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / 2-methyl-propan-2-ol / 24 h / 25 °C

2: 100 percent / N-iodosuccinimide; p-TsOH / tetrahydrofuran / 24.5 h / -20 - 25 °C

3: 99 percent / NaH; Bu₄NI / dimethylformamide / 3 h / 0 - 25 °C

With N-iodo-succinimide; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jo035119f

Reference yield:

: 13130-79-5
3-amino-1-bromoisoquinoline

: 577705-95-4
3-[N-(tert-butyloxycarbonyl)-N-(3-chloroprop-2-en-1-yl)amino]-1-benzyloxy-4-iodoisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / dimethylformamide / 1.5 h / 25 °C

2: 89 percent / 2-methyl-propan-2-ol / 24 h / 25 °C

3: 100 percent / N-iodosuccinimide; p-TsOH / tetrahydrofuran / 24.5 h / -20 - 25 °C

4: 99 percent / NaH; Bu₄NI / dimethylformamide / 3 h / 0 - 25 °C

With N-iodo-succinimide; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jo035119f