(2R)-[(12Z)-13-(2R)-(1-Benzylpyrrolidin-2-yl)tridec-12-en-2-yl]-(2S)-(2-methoxymethylpyrrolidin-1-yl)amine

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Chemical Name:(2R)-[(12Z)-13-(2R)-(1-Benzylpyrrolidin-2-yl)tridec-12-en-2-yl]-(2S)-(2-methoxymethylpyrrolidin-1-yl)amine
CAS No.:274676-71-0
Molecular Formula:C₃₀H₅₁N₃O
Molecular Weight:469.754
Hs Code.:

Synonyms:(2R)-[(12Z)-13-(2R)-(1-Benzylpyrrolidin-2-yl)tridec-12-en-2-yl]-(2S)-(2-methoxymethylpyrrolidin-1-yl)amine

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Chemical Property of (2R)-[(12Z)-13-(2R)-(1-Benzylpyrrolidin-2-yl)tridec-12-en-2-yl]-(2S)-(2-methoxymethylpyrrolidin-1-yl)amine

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Technology Process of (2R)-[(12Z)-13-(2R)-(1-Benzylpyrrolidin-2-yl)tridec-12-en-2-yl]-(2S)-(2-methoxymethylpyrrolidin-1-yl)amine

There total 7 articles about (2R)-[(12Z)-13-(2R)-(1-Benzylpyrrolidin-2-yl)tridec-12-en-2-yl]-(2S)-(2-methoxymethylpyrrolidin-1-yl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 917-54-4
methyllithium

: 274676-70-9
(2R)-[(11Z)-12-(1-Benzylpyrrolidin-2-yl)dodec-11-en-1-ylidene]-(2S)-(2-methoxymethylpyrrolidin-1-yl)amine

: 274676-71-0
(2R)-[(12Z)-13-(2R)-(1-Benzylpyrrolidin-2-yl)tridec-12-en-2-yl]-(2S)-(2-methoxymethylpyrrolidin-1-yl)amine

Guidance literature:: In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; for 15h;
DOI:10.1055/s-2000-6379

Reference yield:

: 1611-56-9
1-Bromo-11-hydroxyundecane

: 274676-71-0
(2R)-[(12Z)-13-(2R)-(1-Benzylpyrrolidin-2-yl)tridec-12-en-2-yl]-(2S)-(2-methoxymethylpyrrolidin-1-yl)amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: (COCl)2; DMSO; Et₃N / -78 - 25 °C

2.1: p-TsOH / toluene / 16 h / Heating

3.1: 98 percent / acetonitrile / 72 h / Heating

4.1: tert-BuLi / tetrahydrofuran; hexane / 0.75 h / -78 - 20 °C

4.2: tetrahydrofuran; hexane / 15 h / -78 - 20 °C

5.1: HCl; H₂O / acetone / 18 h / 25 °C

6.1: 0.5 h / 20 °C

7.1: 94 percent / diethyl ether; tetrahydrofuran / 15 h / -78 - 20 °C

With hydrogenchloride; oxalyl dichloride; water; tert.-butyl lithium; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; diethyl ether; hexane; acetone; toluene; acetonitrile; 1.1: Oxidation / 2.1: Cyclization / 3.1: Alkylation / 4.1: Elimination / 4.2: Condensation / 5.1: Hydrolysis / 6.1: Condensation / 7.1: Addition;
DOI:10.1055/s-2000-6379

Reference yield:

: 70326-40-8
11-bromoundecan-1-al

: 274676-71-0
(2R)-[(12Z)-13-(2R)-(1-Benzylpyrrolidin-2-yl)tridec-12-en-2-yl]-(2S)-(2-methoxymethylpyrrolidin-1-yl)amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: p-TsOH / toluene / 16 h / Heating

2.1: 98 percent / acetonitrile / 72 h / Heating

3.1: tert-BuLi / tetrahydrofuran; hexane / 0.75 h / -78 - 20 °C

3.2: tetrahydrofuran; hexane / 15 h / -78 - 20 °C

4.1: HCl; H₂O / acetone / 18 h / 25 °C

5.1: 0.5 h / 20 °C

6.1: 94 percent / diethyl ether; tetrahydrofuran / 15 h / -78 - 20 °C

With hydrogenchloride; water; tert.-butyl lithium; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; hexane; acetone; toluene; acetonitrile; 1.1: Cyclization / 2.1: Alkylation / 3.1: Elimination / 3.2: Condensation / 4.1: Hydrolysis / 5.1: Condensation / 6.1: Addition;
DOI:10.1055/s-2000-6379