(2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid 1-cyclohexyloxycarbonyloxyethyl ester

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Chemical Name:(2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid 1-cyclohexyloxycarbonyloxyethyl ester
CAS No.:1445563-86-9
Molecular Formula:C₃₃H₃₉F₃N₆O₉S₂
Molecular Weight:784.835
Hs Code.:

(2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid 1-cyclohexyloxycarbonyloxyethyl ester

Synonyms:(2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid 1-cyclohexyloxycarbonyloxyethyl ester

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Chemical Property of (2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid 1-cyclohexyloxycarbonyloxyethyl ester

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Technology Process of (2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid 1-cyclohexyloxycarbonyloxyethyl ester

There total 15 articles about (2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid 1-cyclohexyloxycarbonyloxyethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: (2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid hydrochloride

: 99464-83-2
1-chloroethyl cyclohexyl carbonate

: 1445563-86-9
(2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid 1-cyclohexyloxycarbonyloxyethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 432h; Inert atmosphere;

Reference yield:

: (2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid propyl ester hydrochloride

: 1445563-86-9
(2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid 1-cyclohexyloxycarbonyloxyethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water / 4 h / 80 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 432 h / 20 °C / Inert atmosphere

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide;

Reference yield:

: 1445564-96-4
(E)-3-(3-bromo-4-trifluoromethoxyphenyl)acrylic acid

: 1445563-86-9
(2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid 1-cyclohexyloxycarbonyloxyethyl ester

Guidance literature:: Multi-step reaction with 13 steps

1.1: triethylamine; chloroformic acid ethyl ester / acetone / 1 h / 0 °C

1.2: 1 h / 0 °C

2.1: tributyl-amine / diphenylether / 250 °C / Inert atmosphere

3.1: trichlorophosphate / toluene / 1 h / Reflux

4.1: potassium carbonate; acetamide / water; ethyl acetate / 1 h / 180 °C

5.1: triethylamine / N,N-dimethyl-formamide / 15 h / 50 °C

6.1: tetraethylammonium chloride; sodium hydrogencarbonate; palladium diacetate / N,N-dimethyl-formamide / 2 h / 95 °C

7.1: {(-)-1,2-bis(2R,5R)-2,5-dimethylphospholanobenzene(cyclooctadiene)rhodium(l)} triflate; hydrogen / methanol / 15 h / 20 °C / 3750.38 Torr / Inert atmosphere; Autoclave

8.1: hydrogenchloride / dichloromethane; diethyl ether / 3 h / 0 °C

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C

10.1: titanium(IV) isopropylate / 2 h / Reflux

11.1: hydrogenchloride / water; acetonitrile

12.1: hydrogenchloride / water / 4 h / 80 °C

13.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 432 h / 20 °C / Inert atmosphere

With acetamide; titanium(IV) isopropylate; hydrogenchloride; {(-)-1,2-bis(2R,5R)-2,5-dimethylphospholanobenzene(cyclooctadiene)rhodium(l)} triflate; tributyl-amine; tetraethylammonium chloride; hydrogen; palladium diacetate; chloroformic acid ethyl ester; sodium hydrogencarbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; diphenylether; diethyl ether; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;