(2R,3S)-2-ethyl-3-<<(2R,4S,3S,5S,6R)-2-(4-methoxyphenyl)-5-methyl-4-<(1R,2E)-1-methyl-2-butenyl>>-1,3-dioxan-6-yl>-3-methyl-1,4-dioxaspiro<4.4>nonane

Base Information

Chemical Name:(2R,3S)-2-ethyl-3-<<(2R,4S,3S,5S,6R)-2-(4-methoxyphenyl)-5-methyl-4-<(1R,2E)-1-methyl-2-butenyl>>-1,3-dioxan-6-yl>-3-methyl-1,4-dioxaspiro<4.4>nonane
CAS No.:147033-10-1
Molecular Formula:C₂₇H₄₀O₅
Molecular Weight:444.612
Hs Code.:

Synonyms:(2R,3S)-2-ethyl-3-<<(2R,4S,3S,5S,6R)-2-(4-methoxyphenyl)-5-methyl-4-<(1R,2E)-1-methyl-2-butenyl>>-1,3-dioxan-6-yl>-3-methyl-1,4-dioxaspiro<4.4>nonane

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Chemical Property of (2R,3S)-2-ethyl-3-<<(2R,4S,3S,5S,6R)-2-(4-methoxyphenyl)-5-methyl-4-<(1R,2E)-1-methyl-2-butenyl>>-1,3-dioxan-6-yl>-3-methyl-1,4-dioxaspiro<4.4>nonane

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Technology Process of (2R,3S)-2-ethyl-3-<<(2R,4S,3S,5S,6R)-2-(4-methoxyphenyl)-5-methyl-4-<(1R,2E)-1-methyl-2-butenyl>>-1,3-dioxan-6-yl>-3-methyl-1,4-dioxaspiro<4.4>nonane

There total 5 articles about (2R,3S)-2-ethyl-3-<<(2R,4S,3S,5S,6R)-2-(4-methoxyphenyl)-5-methyl-4-<(1R,2E)-1-methyl-2-butenyl>>-1,3-dioxan-6-yl>-3-methyl-1,4-dioxaspiro<4.4>nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 147033-09-8
(2R,3S)-2-ethyl-3-<(1R,2S,3S,4R,5E)-3-hydroxy-1-(4-methoxybenzyloxy)-2,4-dimethyl-5-heptenyl>-3-methyl-1,4-dioxaspiro<4.4>nonane

: 147033-10-1
(2R,3S)-2-ethyl-3-<<(2R,4S,3S,5S,6R)-2-(4-methoxyphenyl)-5-methyl-4-<(1R,2E)-1-methyl-2-butenyl>>-1,3-dioxan-6-yl>-3-methyl-1,4-dioxaspiro<4.4>nonane

Guidance literature:: With molecular sieve; 2,3-dicyano-5,6-dichloro-p-benzoquinone; at 0 ℃;

Reference yield:

: 120788-81-0
(2R,3R)-3-ethyl-2-methyl-1,4-dioxaspiro<4.4>nonane-2-carbaldehyde

: 147033-10-1
(2R,3S)-2-ethyl-3-<<(2R,4S,3S,5S,6R)-2-(4-methoxyphenyl)-5-methyl-4-<(1R,2E)-1-methyl-2-butenyl>>-1,3-dioxan-6-yl>-3-methyl-1,4-dioxaspiro<4.4>nonane

Guidance literature:: Multi-step reaction with 5 steps

1: 81 percent / benzene / 48 h / Heating

2: 1.) 80percent NaH / white oil / 1.) DMF, 10 min; 2.) DMF, 12 h

3: 1.) O₃/O₂; 2.) Ph₃P / 1.) CH₂Cl₂, -78 deg C; 2.) CH₂Cl₂, -78 deg C to 0 deg C

4: 79 percent / molecular sieves (3 Angstroem) / petroleum ether / 48 h / 25 °C

5: 91 percent / molecular sieves (3 Angstroem), 2,3-dichloro-4,5-dicyanobenzoquinone / CH₂Cl₂ / 6 h / 0 °C

With 3 A molecular sieve; oxygen; sodium hydride; ozone; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; white oil; In dichloromethane; Petroleum ether; benzene;

Reference yield:

: 120788-82-1
(2R,3S)-2-ethyl-3-<(1R,2S,3E)-1-hydroxy-2-methyl-3-pentenyl>-3-methyl-1,4-dioxaspiro<4.4>nonane

: 147033-10-1
(2R,3S)-2-ethyl-3-<<(2R,4S,3S,5S,6R)-2-(4-methoxyphenyl)-5-methyl-4-<(1R,2E)-1-methyl-2-butenyl>>-1,3-dioxan-6-yl>-3-methyl-1,4-dioxaspiro<4.4>nonane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 80percent NaH / white oil / 1.) DMF, 10 min; 2.) DMF, 12 h

2: 1.) O₃/O₂; 2.) Ph₃P / 1.) CH₂Cl₂, -78 deg C; 2.) CH₂Cl₂, -78 deg C to 0 deg C

3: 79 percent / molecular sieves (3 Angstroem) / petroleum ether / 48 h / 25 °C

4: 91 percent / molecular sieves (3 Angstroem), 2,3-dichloro-4,5-dicyanobenzoquinone / CH₂Cl₂ / 6 h / 0 °C

With 3 A molecular sieve; oxygen; sodium hydride; ozone; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; white oil; In dichloromethane; Petroleum ether;