(2R,3R,4S)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3-methyl-hexane-2,4-diol

Base Information

Chemical Name:(2R,3R,4S)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3-methyl-hexane-2,4-diol
CAS No.:261775-40-0
Molecular Formula:C₃₀H₄₀O₄Si
Molecular Weight:492.731
Hs Code.:

Synonyms:(2R,3R,4S)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3-methyl-hexane-2,4-diol

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Chemical Property of (2R,3R,4S)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3-methyl-hexane-2,4-diol

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Technology Process of (2R,3R,4S)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3-methyl-hexane-2,4-diol

There total 6 articles about (2R,3R,4S)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3-methyl-hexane-2,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 261775-38-6
6-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-methyl-hex-4-en-3-ol

: 261775-40-0
(2R,3R,4S)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3-methyl-hexane-2,4-diol

Guidance literature:: Multi-step reaction with 2 steps

1: tert-butyl hydroperoxide; 4-Angstroem molecular sieves / diisopropyl (-)-D-tartrate; Ti(iPrO)4 / CH₂Cl₂ / 0.42 h / -20 °C

2: Cp₂TiCl; cyclohexa-1,4-diene / tetrahydrofuran / 8 h / -20 - 20 °C

With tert.-butylhydroperoxide; bis(cyclopentadienyl)titanium (III) chloride; cyclohexa-1,4-diene; 4 A molecular sieve; titanium(IV) isopropylate; D-(-)-diisopropyl tartrate; In tetrahydrofuran; dichloromethane; 1: Sharpless asymmetric epoxidation;
DOI:10.1021/jo010131y

Reference yield:

: (S)-1-((S)-3-Benzyloxymethyl-2-methyl-oxiranyl)-3-(tert-butyl-diphenyl-silanyloxy)-propan-1-ol

: 261775-40-0
(2R,3R,4S)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3-methyl-hexane-2,4-diol

Guidance literature:: With bis(cyclopentadienyl)titanium (III) chloride; cyclohexa-1,4-diene; In tetrahydrofuran; at -20 - 20 ℃; for 8h;
DOI:10.1021/jo010131y

Reference yield:

: 261775-37-5
(S)-1-((2S,3S)-3-Benzyloxymethyl-2-methyl-oxiranyl)-3-(tert-butyl-diphenyl-silanyloxy)-propan-1-ol

: (2R,3S,4S)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3-methyl-hexane-2,4-diol

: 261775-40-0
(2R,3R,4S)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3-methyl-hexane-2,4-diol

Guidance literature:: With bis(cyclopentadienyl)titanium dichloride; cyclohexa-1,4-diene; zinc(II) chloride; In tetrahydrofuran; at -20 - 20 ℃; for 6h; Title compound not separated from byproducts;