2-fluoro-3-methyl-4-(isobutyryl)aminophenyl iodide

Base Information

Chemical Name:2-fluoro-3-methyl-4-(isobutyryl)aminophenyl iodide
CAS No.:1364739-71-8
Molecular Formula:C₁₁H₁₃FINO
Molecular Weight:321.133
Hs Code.:

Synonyms:2-fluoro-3-methyl-4-(isobutyryl)aminophenyl iodide

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Chemical Property of 2-fluoro-3-methyl-4-(isobutyryl)aminophenyl iodide

Chemical Property:

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Technology Process of 2-fluoro-3-methyl-4-(isobutyryl)aminophenyl iodide

There total 2 articles about 2-fluoro-3-methyl-4-(isobutyryl)aminophenyl iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 443-86-7
3-fluoro-2-methylaniline

: 79-30-1
isobutyryl chloride

: 1364739-71-8
2-fluoro-3-methyl-4-(isobutyryl)aminophenyl iodide

Guidance literature:: 3-fluoro-2-methylaniline; With sodium perborate; potassium iodide; In water; acetic acid; at 5 - 20 ℃; for 1.5h;

isobutyryl chloride; With 4-methyl-morpholine; In tetrahydrofuran; at 0 - 10 ℃; for 1h; chemoselective reaction;
DOI:10.1021/op200301h

Reference yield:

: 329927-16-4
2-fluoro-3-methyl-4-aminophenyl iodide

: 1364739-71-8
2-fluoro-3-methyl-4-(isobutyryl)aminophenyl iodide

Guidance literature:: Multi-step reaction with 2 steps

1.1: para-methylphenylmagnesium bromide / tetrahydrofuran

2.1: sodium perborate; potassium iodide / water; acetic acid / 1.5 h / 5 - 20 °C

2.2: 1 h / 0 - 10 °C

With sodium perborate; para-methylphenylmagnesium bromide; potassium iodide; In tetrahydrofuran; water; acetic acid;
DOI:10.1021/op200301h

Reference yield: 90.0%

: 124-38-9,18923-20-1
carbon dioxide

: 1364739-71-8
2-fluoro-3-methyl-4-(isobutyryl)aminophenyl iodide

: 1340148-03-9
C₁₁H₁₄FNO

: 1364740-20-4
C₁₂H₁₄FNO₃

Guidance literature:: 2-fluoro-3-methyl-4-(isobutyryl)aminophenyl iodide; With para-methylphenylmagnesium bromide; In tetrahydrofuran; at -10 - 0 ℃; for 0.5h;

With isopropylmagnesium chloride; In tetrahydrofuran; at -10 - 0 ℃; for 0.5h;

carbon dioxide; In tetrahydrofuran; at -10 - 15 ℃; for 0.333333h;
DOI:10.1021/op200301h