N-cyclopropyl-4-{8-[(2-methylpropyl)amino]-6-(pyridin-4-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide

Base Information

Chemical Name:N-cyclopropyl-4-{8-[(2-methylpropyl)amino]-6-(pyridin-4-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide
CAS No.:1263421-65-3
Molecular Formula:C₂₅H₂₆N₆O
Molecular Weight:426.521
Hs Code.:

Synonyms:N-cyclopropyl-4-{8-[(2-methylpropyl)amino]-6-(pyridin-4-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide

Suppliers and Price of N-cyclopropyl-4-{8-[(2-methylpropyl)amino]-6-(pyridin-4-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-cyclopropyl-4-{8-[(2-methylpropyl)amino]-6-(pyridin-4-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-cyclopropyl-4-{8-[(2-methylpropyl)amino]-6-(pyridin-4-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide

There total 4 articles about N-cyclopropyl-4-{8-[(2-methylpropyl)amino]-6-(pyridin-4-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1263421-51-7
4-(6-bromo-8-isobutylamino-imidazo[1,2-a]pyrazin-3-yl)-N-cyclopropyl-benzamide

: 1692-15-5
4-pyridylboronic acid

: 1263421-65-3
N-cyclopropyl-4-{8-[(2-methylpropyl)amino]-6-(pyridin-4-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide

Guidance literature:: With potassium carbonate; tris-(o-tolyl)phosphine; palladium diacetate; In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 1.33333h; Sealed vial; Microwave irradiation;

Reference yield:

: 860173-33-7
4-(cyclopropylaminocarbonyl)phenylboronic acid pinacol ester

: 1263421-65-3
N-cyclopropyl-4-{8-[(2-methylpropyl)amino]-6-(pyridin-4-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 72 h / 40 °C / Inert atmosphere

2: potassium carbonate; tris-(o-tolyl)phosphine / palladium diacetate / 1-methyl-pyrrolidin-2-one / 1.33 h / 140 °C / Sealed vial; Microwave irradiation

With potassium phosphate; potassium carbonate; tris-(o-tolyl)phosphine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water;

Reference yield:

: 1351374-43-0
N-(6-bromo-3-iodoimidazo[1,2-a]pyrazin-8-yl)propane-1,3-diamine

: 1263421-65-3
N-cyclopropyl-4-{8-[(2-methylpropyl)amino]-6-(pyridin-4-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 72 h / 40 °C / Inert atmosphere

2: potassium carbonate; tris-(o-tolyl)phosphine / palladium diacetate / 1-methyl-pyrrolidin-2-one / 1.33 h / 140 °C / Sealed vial; Microwave irradiation

With potassium phosphate; potassium carbonate; tris-(o-tolyl)phosphine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water;