tert-butyl ((S)-3-cyclohexyl-1-((R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)carbamate

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Chemical Name:tert-butyl ((S)-3-cyclohexyl-1-((R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)carbamate
CAS No.:1620107-77-8
Molecular Formula:C₁₇H₂₉NO₄
Molecular Weight:311.422
Hs Code.:

Synonyms:tert-butyl ((S)-3-cyclohexyl-1-((R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)carbamate

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Chemical Property of tert-butyl ((S)-3-cyclohexyl-1-((R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)carbamate

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Technology Process of tert-butyl ((S)-3-cyclohexyl-1-((R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)carbamate

There total 8 articles about tert-butyl ((S)-3-cyclohexyl-1-((R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: C₁₇H₃₁NO₃

: 1620107-77-8
tert-butyl ((S)-3-cyclohexyl-1-((R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)carbamate

Guidance literature:: C₁₇H₃₁NO₃; With tert.-butylhydroperoxide; bis(acetylacetonate)oxovanadium; In decane; dichloromethane; at 0 ℃; for 2h;

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 20h;
DOI:10.1021/jacs.9b11969

Reference yield: 41.0%

: 1620107-67-6
(S)-tert-butyl (1-cyclohexyl-4-methyl-3-oxopent-4-en-2-yl)carbamate

: 1620107-77-8
tert-butyl ((S)-3-cyclohexyl-1-((R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)carbamate

Guidance literature:: With dihydrogen peroxide; benzonitrile; N-ethyl-N,N-diisopropylamine; In methanol; at 0 ℃;
DOI:10.1021/acs.jmedchem.0c00416

Reference yield:

: 37736-82-6
(S)-2-tert-butoxycarbonylamino-3-cyclohexylpropionic acid

: 1620107-77-8
tert-butyl ((S)-3-cyclohexyl-1-((R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2-(6-chloro-1H-benzotriazole-1-yl)21,1,3,3-tetramethylaminiumhexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane

2.1: tert.-butyl lithium / diethyl ether / 0.25 h / -78 °C

2.2: -78 - -40 °C

3.1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 0.67 h / 0 °C

4.1: tert.-butylhydroperoxide; bis(acetylacetonate)oxovanadium / dichloromethane; decane / 0 °C

5.1: Dess-Martin periodane / dichloromethane / 0 °C

With tert.-butylhydroperoxide; sodium tetrahydroborate; bis(acetylacetonate)oxovanadium; cerium(III) chloride heptahydrate; 2-(6-chloro-1H-benzotriazole-1-yl)21,1,3,3-tetramethylaminiumhexafluorophosphate; tert.-butyl lithium; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; decane; dichloromethane;
DOI:10.1021/jm500716s