Technology Process of (R)-2-(4-phenylbutan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
There total 27 articles about (R)-2-(4-phenylbutan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 20 ℃;
for 3h;
DOI:10.1021/jacs.6b07396
- Guidance literature:
-
ethyl diisopropylcarbamate;
With
sec.-butyllithium; (-)-sparteine;
In
diethyl ether;
at -78 ℃;
for 5h;
Inert atmosphere;
Schlenk technique;
4,4,5,5-tetramethyl-2-phenethyl-1,3,2-dioxaborolane;
In
diethyl ether;
at -78 ℃;
for 1h;
Inert atmosphere;
Schlenk technique;
With
magnesium bromide ethyl etherate;
In
diethyl ether;
for 16h;
Inert atmosphere;
Schlenk technique;
Reflux;
DOI:10.1021/jacs.6b03963
- Guidance literature:
-
(R)-4-phenylbutan-2-yl 2,4,6-triisopropylbenzoate;
With
N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium;
In
hexane; cyclohexane;
at -60 ℃;
for 2h;
Inert atmosphere;
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane;
In
diethyl ether; hexane; cyclohexane;
at -60 - 90 ℃;
for 17h;
stereospecific reaction;
Inert atmosphere;
DOI:10.1039/c4cc00993b
