(1R,2S,3R,4S)-3-(1,1'-biphenyl-4-ylamino)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol

Base Information

Chemical Name:(1R,2S,3R,4S)-3-(1,1'-biphenyl-4-ylamino)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol
CAS No.:1392477-51-8
Molecular Formula:C₂₂H₂₇NO
Molecular Weight:321.462
Hs Code.:

Synonyms:(1R,2S,3R,4S)-3-(1,1'-biphenyl-4-ylamino)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol

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Chemical Property of (1R,2S,3R,4S)-3-(1,1'-biphenyl-4-ylamino)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol

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Technology Process of (1R,2S,3R,4S)-3-(1,1'-biphenyl-4-ylamino)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol

There total 3 articles about (1R,2S,3R,4S)-3-(1,1'-biphenyl-4-ylamino)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1392477-47-2
(1R,3R,4S)-(1',1''-biphenyl-4'-ylamino)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one

: 1392477-51-8
(1R,2S,3R,4S)-3-(1,1'-biphenyl-4-ylamino)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol

Guidance literature:: With sodium tetrahydroborate; In isopropyl alcohol; at 20 ℃; stereoselective reaction; Inert atmosphere;
DOI:10.1007/s10600-012-0261-x

Reference yield:

: (1R)-3-(biphenylyl-⁽⁴⁾-imino)-bornanone-⁽²⁾

: 1392477-51-8
(1R,2S,3R,4S)-3-(1,1'-biphenyl-4-ylamino)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / benzene

2: sodium tetrahydroborate / isopropyl alcohol / 20 °C / Inert atmosphere

With sodium tetrahydroborate; sodium tris(acetoxy)borohydride; In isopropyl alcohol; benzene;
DOI:10.1007/s10600-012-0261-x

Reference yield:

: 92-67-1
4-phenylalanine

: 1392477-51-8
(1R,2S,3R,4S)-3-(1,1'-biphenyl-4-ylamino)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: boron trifluoride diethyl etherate / benzene / Reflux

2: sodium tris(acetoxy)borohydride / benzene

3: sodium tetrahydroborate / isopropyl alcohol / 20 °C / Inert atmosphere

With sodium tetrahydroborate; boron trifluoride diethyl etherate; sodium tris(acetoxy)borohydride; In isopropyl alcohol; benzene;
DOI:10.1007/s10600-012-0261-x