(Benzyloxycarbonyl)-β-homo-L-aspartic acid α-pentachlorophenyl ester β-tert-butyl ester

Base Information

Chemical Name:(Benzyloxycarbonyl)-β-homo-L-aspartic acid α-pentachlorophenyl ester β-tert-butyl ester
CAS No.:118247-80-6
Molecular Formula:C₂₃H₂₂Cl₅NO₆
Molecular Weight:585.696
Hs Code.:

Synonyms:(Benzyloxycarbonyl)-β-homo-L-aspartic acid α-pentachlorophenyl ester β-tert-butyl ester

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Chemical Property of (Benzyloxycarbonyl)-β-homo-L-aspartic acid α-pentachlorophenyl ester β-tert-butyl ester

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Technology Process of (Benzyloxycarbonyl)-β-homo-L-aspartic acid α-pentachlorophenyl ester β-tert-butyl ester

There total 4 articles about (Benzyloxycarbonyl)-β-homo-L-aspartic acid α-pentachlorophenyl ester β-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 87-86-5,67471-28-7
Pentachlorophenol

: 83436-45-7
(3R)-3-benzyloxycarbonylamino-4-tert-butyoxycarbonylbutyric acid

: 118247-80-6
(Benzyloxycarbonyl)-β-homo-L-aspartic acid α-pentachlorophenyl ester β-tert-butyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1021/jm00123a003

Reference yield:

: 5545-52-8
Z-D(tBu)-OH

: 118247-80-6
(Benzyloxycarbonyl)-β-homo-L-aspartic acid α-pentachlorophenyl ester β-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) DME, -20 deg C, 5 min, 2.) DME, ether, 0 deg C, 20 min

2: silver benzoate, triethylamine / 30 h / Ambient temperature

3: 2 N NaOH / methanol / 0.5 h / 30 °C

4: 72 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 2 h / 0 °C

With 4-methyl-morpholine; sodium hydroxide; silver benzoate; triethylamine; dicyclohexyl-carbodiimide; isobutyl chloroformate; In methanol; dichloromethane;
DOI:10.1021/jm00123a003

Reference yield:

: 83436-44-6
Z-β-homo-Asp(OBut)-OMe

: 118247-80-6
(Benzyloxycarbonyl)-β-homo-L-aspartic acid α-pentachlorophenyl ester β-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 2 N NaOH / methanol / 0.5 h / 30 °C

2: 72 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 2 h / 0 °C

With sodium hydroxide; dicyclohexyl-carbodiimide; In methanol; dichloromethane;
DOI:10.1021/jm00123a003