(rac)-N-[4-(4-cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl]-N'-propylsulfuric diamide

Base Information

Chemical Name:(rac)-N-[4-(4-cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl]-N'-propylsulfuric diamide
CAS No.:1469978-61-7
Molecular Formula:C₁₉H₂₂N₄O₂S
Molecular Weight:370.475
Hs Code.:

Synonyms:(rac)-N-[4-(4-cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl]-N'-propylsulfuric diamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (rac)-N-[4-(4-cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl]-N'-propylsulfuric diamide

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Technology Process of (rac)-N-[4-(4-cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl]-N'-propylsulfuric diamide

There total 6 articles about (rac)-N-[4-(4-cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl]-N'-propylsulfuric diamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 10305-42-7
N-propylsulfamoyl chloride

: 1469978-59-3
(rac)-4-(8-amino-5,6,7,8-tetrahydroisoquinolin-4-yl)benzonitrile

: 1469978-61-7
(rac)-N-[4-(4-cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl]-N'-propylsulfuric diamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2.5h; Inert atmosphere;

Reference yield:

: 1428651-86-8
4-bromo-6,7-dihydroisoquinolin-8(5H)-one

: 1469978-61-7
(rac)-N-[4-(4-cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl]-N'-propylsulfuric diamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium(IV) isopropylate; ammonia / methanol / 5 h / 20 °C / Inert atmosphere

1.2: 2.17 h / 20 °C / Inert atmosphere

2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ethanol / 85 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

With titanium(IV) isopropylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; sodium carbonate; triethylamine; In methanol; ethanol; dichloromethane; water; 2.1: |Suzuki Coupling;

Reference yield:

: 1428651-84-6
ethyl 5-bromo-4-methylnicotinate

: 1469978-61-7
(rac)-N-[4-(4-cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl]-N'-propylsulfuric diamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere

1.2: 1.75 h / Inert atmosphere

2.1: hydrogenchloride / water / 2.5 h / Inert atmosphere; Reflux

3.1: titanium(IV) isopropylate; ammonia / methanol / 5 h / 20 °C / Inert atmosphere

3.2: 2.17 h / 20 °C / Inert atmosphere

4.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ethanol / 85 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

With titanium(IV) isopropylate; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; sodium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; 4.1: |Suzuki Coupling;