Technology Process of (3αS,4S,7αR)-2,2,4,7α-tetramethyl-6-(phenylsulfonyl)-3α,4,5,7α-tetrahydrobenzo[δ][1,3]dioxole
There total 2 articles about (3αS,4S,7αR)-2,2,4,7α-tetramethyl-6-(phenylsulfonyl)-3α,4,5,7α-tetrahydrobenzo[δ][1,3]dioxole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran;
for 16h;
Heating;
DOI:10.1021/ja00385a030
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 14.3 g / m-chloroperbenzoic acid / CH2Cl2 / 1.) -35 deg C, 10 min, 2.) -35 deg C -> 25 deg C, 1 h
2: 86 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / tetrahydrofuran / 16 h / Heating
With
1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00385a030
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) n-BuLi, t-BuOK / 1a.) THF, hexane, -78 deg C, 30 min, 1b.) from -78 deg C to -45 deg C, 30 min, 2.) 0 deg C, 10 min
2: n-BuLi, t-BuOK / tetrahydrofuran; hexane / 2 h / 25 °C
3: 1.) BH3*THF, cyclohexene, 2.) 1.8 M aq. potassium hydroxide, 10 M hydrogen peroxide / 1.) THF, 25 deg C, 15 min, 2.) 0 deg C, 1 h
4: 50 percent / H2 / 10percent Pd/C / ethanol / 36 h / 760 Torr
With
potassium hydroxide; n-butyllithium; borane-THF; potassium tert-butylate; hydrogen; dihydrogen peroxide; cyclohexene;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; hexane;
