benzyl-(2S,5S)-5-carboxymethyl prolinate

Base Information

Chemical Name:benzyl-(2S,5S)-5-carboxymethyl prolinate
CAS No.:571200-57-2
Molecular Formula:C₁₄H₁₇NO₄
Molecular Weight:263.293
Hs Code.:

Synonyms:benzyl-(2S,5S)-5-carboxymethyl prolinate

Suppliers and Price of benzyl-(2S,5S)-5-carboxymethyl prolinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of benzyl-(2S,5S)-5-carboxymethyl prolinate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzyl-(2S,5S)-5-carboxymethyl prolinate

There total 4 articles about benzyl-(2S,5S)-5-carboxymethyl prolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(Boc)-(2S)-(5-(tert-butyl)carboxymethyl)proline benzyl ester

: 571200-57-2
benzyl-(2S,5S)-5-carboxymethyl prolinate

: benzyl-(2S,5R)-5-carboxymethyl prolinate

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 0.5h; Title compound not separated from byproducts;
DOI:10.1021/ja034248a

Reference yield:

: 603127-31-7
6-tert-butoxycarbonylamino-hept-2-enedioic acid 7-benzyl ester 1-tert-butyl ester

: 571200-57-2
benzyl-(2S,5S)-5-carboxymethyl prolinate

Guidance literature:: 6-tert-butoxycarbonylamino-hept-2-enedioic acid 7-benzyl ester 1-tert-butyl ester; With hydrogenchloride; In diethyl ether; for 5h;

With triethylamine; In tetrahydrofuran; for 48h;
DOI:10.1016/S0040-4039(02)02731-4

Reference yield:

: 30924-93-7
Boc-Glu-OBn

: 571200-57-2
benzyl-(2S,5S)-5-carboxymethyl prolinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: (COCl)2 / dimethylformamide; acetonitrile; tetrahydrofuran / 1 h / -30 °C

1.2: 82 percent / LiAlH(OtBu)3 / dimethylformamide; acetonitrile; tetrahydrofuran / 1 h / -78 °C

2.1: 86 percent / toluene / 12 h / 110 °C

3.1: HCl / diethyl ether / 5 h

3.2: Et₃N / tetrahydrofuran / 48 h

With hydrogenchloride; oxalyl dichloride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; toluene; acetonitrile; 2.1: Wittig olefination;
DOI:10.1016/S0040-4039(02)02731-4