(8S,9S,10S,13R,14S,17R)-17-[(R)-6-(tert-Butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyl]-13-methyl-3-oxo-1,2,3,6,7,8,9,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthrene-10-carboxylic acid

Base Information

Chemical Name:(8S,9S,10S,13R,14S,17R)-17-[(R)-6-(tert-Butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyl]-13-methyl-3-oxo-1,2,3,6,7,8,9,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthrene-10-carboxylic acid
CAS No.:137435-86-0
Molecular Formula:C₄₃H₆₀O₄Si
Molecular Weight:669.033
Hs Code.:

(8S,9S,10S,13R,14S,17R)-17-[(R)-6-(tert-Butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyl]-13-methyl-3-oxo-1,2,3,6,7,8,9,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthrene-10-carboxylic acid

Synonyms:(8S,9S,10S,13R,14S,17R)-17-[(R)-6-(tert-Butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyl]-13-methyl-3-oxo-1,2,3,6,7,8,9,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthrene-10-carboxylic acid

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Chemical Property of (8S,9S,10S,13R,14S,17R)-17-[(R)-6-(tert-Butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyl]-13-methyl-3-oxo-1,2,3,6,7,8,9,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthrene-10-carboxylic acid

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Technology Process of (8S,9S,10S,13R,14S,17R)-17-[(R)-6-(tert-Butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyl]-13-methyl-3-oxo-1,2,3,6,7,8,9,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthrene-10-carboxylic acid

There total 11 articles about (8S,9S,10S,13R,14S,17R)-17-[(R)-6-(tert-Butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyl]-13-methyl-3-oxo-1,2,3,6,7,8,9,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthrene-10-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 137435-85-9
(25ξ)-26-<(tert-butyldiphenylsilyl)oxy>-19-hydroxycholest-4-en-3-one

: 137435-86-0
(8S,9S,10S,13R,14S,17R)-17-[(R)-6-(tert-Butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyl]-13-methyl-3-oxo-1,2,3,6,7,8,9,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthrene-10-carboxylic acid

Guidance literature:: With jones' reagent; In acetone; at 0 ℃; for 2h;

Reference yield:

: 57984-04-0,71424-84-5,71424-85-6
6β-methoxy-3α,5-cyclo-5α-chol-23-en-22-ol

: 137435-86-0
(8S,9S,10S,13R,14S,17R)-17-[(R)-6-(tert-Butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyl]-13-methyl-3-oxo-1,2,3,6,7,8,9,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthrene-10-carboxylic acid

Guidance literature:: Multi-step reaction with 11 steps

1: 76 percent / propionic acid / xylene / 3 h / Heating

2: 100 percent / H₂ / PtO₂ / hexane / 30 h / 760 Torr

3: 6.7 g / LAH / diethyl ether / 0.5 h / Ambient temperature

4: 98 percent / imidazole / dimethylformamide / 1 h

5: 89 percent / 0.67 h / Heating

6: 50 percent / N-bromosuccinimide (NBS), aq. HClO₄ / 1.5 h / 0 - 20 °C

7: 75 percent / Pb(OAc)4, CaCO₃, I₂ / cyclohexane / 3 h / Heating; Irradiation

8: 1.10 g / KOH / methanol / 0.5 h / Heating

9: 8 N Jones' reagent / acetone / 1 h / 0 °C

10: 62 percent / Zn, i-PrOH / dimethylformamide / 8 h / Heating

11: 89 percent / 8 N Jones' reagent / acetone / 2 h / 0 °C

With 1H-imidazole; lead(IV) acetate; potassium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; perchloric acid; jones' reagent; hydrogen; iodine; propionic acid; isopropyl alcohol; calcium carbonate; zinc; platinum(IV) oxide; In methanol; diethyl ether; hexane; cyclohexane; N,N-dimethyl-formamide; acetone; xylene;

Reference yield:

: 137436-15-8
ethyl (25ξ,22E)-6β-methoxy-3α,5-cyclo-5α-cholest-22-en-26-oate

: 137435-86-0
(8S,9S,10S,13R,14S,17R)-17-[(R)-6-(tert-Butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyl]-13-methyl-3-oxo-1,2,3,6,7,8,9,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthrene-10-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1: 100 percent / H₂ / PtO₂ / hexane / 30 h / 760 Torr

2: 6.7 g / LAH / diethyl ether / 0.5 h / Ambient temperature

3: 98 percent / imidazole / dimethylformamide / 1 h

4: 89 percent / 0.67 h / Heating

5: 50 percent / N-bromosuccinimide (NBS), aq. HClO₄ / 1.5 h / 0 - 20 °C

6: 75 percent / Pb(OAc)4, CaCO₃, I₂ / cyclohexane / 3 h / Heating; Irradiation

7: 1.10 g / KOH / methanol / 0.5 h / Heating

8: 8 N Jones' reagent / acetone / 1 h / 0 °C

9: 62 percent / Zn, i-PrOH / dimethylformamide / 8 h / Heating

10: 89 percent / 8 N Jones' reagent / acetone / 2 h / 0 °C

With 1H-imidazole; lead(IV) acetate; potassium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; perchloric acid; jones' reagent; hydrogen; iodine; isopropyl alcohol; calcium carbonate; zinc; platinum(IV) oxide; In methanol; diethyl ether; hexane; cyclohexane; N,N-dimethyl-formamide; acetone;