2,4-dimethoxybenzyl O-{[(6-chloro-1H-benzotriazol-1-yl)oxy]methyl}-N-trityl-D-tyrosinate

Base Information

Chemical Name:2,4-dimethoxybenzyl O-{[(6-chloro-1H-benzotriazol-1-yl)oxy]methyl}-N-trityl-D-tyrosinate
CAS No.:1417187-84-8
Molecular Formula:C₄₄H₃₉ClN₄O₆
Molecular Weight:755.27
Hs Code.:

Synonyms:2,4-dimethoxybenzyl O-{[(6-chloro-1H-benzotriazol-1-yl)oxy]methyl}-N-trityl-D-tyrosinate

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Chemical Property of 2,4-dimethoxybenzyl O-{[(6-chloro-1H-benzotriazol-1-yl)oxy]methyl}-N-trityl-D-tyrosinate

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Technology Process of 2,4-dimethoxybenzyl O-{[(6-chloro-1H-benzotriazol-1-yl)oxy]methyl}-N-trityl-D-tyrosinate

There total 4 articles about 2,4-dimethoxybenzyl O-{[(6-chloro-1H-benzotriazol-1-yl)oxy]methyl}-N-trityl-D-tyrosinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 1417189-01-5
2,4-dimethoxybenzyl O-[(methylsulfanyl)methyl]-N-trityl-D-tyrosinate

: 1417189-04-8
tetrabutylammonium 6-chloro-1-hydroxybenzotriazolate

: 1417187-84-8
2,4-dimethoxybenzyl O-{[(6-chloro-1H-benzotriazol-1-yl)oxy]methyl}-N-trityl-D-tyrosinate

Guidance literature:: 2,4-dimethoxybenzyl O-[(methylsulfanyl)methyl]-N-trityl-D-tyrosinate; With N-chloro-succinimide; In dichloromethane; at -15 ℃; for 4h;

tetrabutylammonium 6-chloro-1-hydroxybenzotriazolate; In dichloromethane-d2; for 1h;

Reference yield:

: 1417189-00-4
2,4-dimethoxybenzyl N-trityl-D-tyrosinate

: 1417187-84-8
2,4-dimethoxybenzyl O-{[(6-chloro-1H-benzotriazol-1-yl)oxy]methyl}-N-trityl-D-tyrosinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h

1.2: 20 h

2.1: N-chloro-succinimide / dichloromethane / 4 h / -15 °C

2.2: 1 h

With N-chloro-succinimide; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1417188-97-6
N-trityl-D-tyrosine

: 1417187-84-8
2,4-dimethoxybenzyl O-{[(6-chloro-1H-benzotriazol-1-yl)oxy]methyl}-N-trityl-D-tyrosinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.25 h

1.2: 16 h

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h

2.2: 20 h

3.1: N-chloro-succinimide / dichloromethane / 4 h / -15 °C

3.2: 1 h

With N-chloro-succinimide; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;